Evidence map›Paper›PMID 42708973›Full record

ArticleMicrobiologyOpen2026

Malassezia May Contribute to Basal Cell Carcinoma Development via Inflammatory and Oxidative Stress Pathways.

Xiaolei Zhu, Wen Zhang, Tinghong Ye, Heng Zhang, Jufang Tan, Yi Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MicrobiologyOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaolei ZhuDepartment of Dermatology, Hubei Provincial Clinical Research Center for Diagnosis and Therapeutics of Pathogenic Fungal Infection, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, China.
Wen ZhangDepartment of Dermatology, Hubei Provincial Clinical Research Center for Diagnosis and Therapeutics of Pathogenic Fungal Infection, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, China.
Tinghong YeDepartment of Pharmacy, Hubei Provincial Clinical Research Center for Diagnosis and Therapeutics of Pathogenic Fungal Infection, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, China.ORCID https://orcid.org/0009-0002-8936-2552
Heng ZhangDepartment of Dermatology, Hubei Provincial Clinical Research Center for Diagnosis and Therapeutics of Pathogenic Fungal Infection, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, China.ORCID https://orcid.org/0009-0002-6618-5311
Jufang TanDepartment of Neonatology, Hubei Provincial Clinical Research Center for Diagnosis and Therapeutics of Pathogenic Fungal Infection, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, China.
Yi SunDepartment of Dermatology, Hubei Provincial Clinical Research Center for Diagnosis and Therapeutics of Pathogenic Fungal Infection, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, China.ORCID https://orcid.org/0000-0002-4489-3803

Funding

Jingzhou Science and Technology Plan Project 2025HD18Key Research and Development Program of Hubei Province 2024BCB043Natural Science Foundation of Hubei Province 2024AFC034Yangtze University Science and Technology Aid to Tibet Medical Talent Training Program Project 2023YZ06
6 · The paper itself

Abstract

Basal cell carcinoma (BCC) is the most common malignant skin tumor. Skin-resident lipophilic Malassezia yeasts are associated with various cutaneous disorders, while their correlative patterns and potential biological effects in BCC tissues remain insufficiently defined. We used RT-qPCR screening of archived FFPE BCC specimens and metagenomic sequencing of three paired fresh tumor and peritumoral tissues to characterize tissue-associated Malassezia colonization. M. globosa was the most abundant species in FFPE samples and was also detectable in fresh tissues. In vitro functional assays (CCK-8, EdU) in HaCaT keratinocytes and A-431 epidermoid carcinoma cells showed that 12 h stimulation with optimal concentrations of M. globosa (1.2 × 10

Indexed as

Basal Cell CarcinomaInflammationMalasseziaOxidative StressSkin NeoplasmsCell Line, TumorCell ProliferationGene Expression ProfilingHumansInterleukin-1betaKeratinocytesSuperoxide DismutaseSuperoxide Dismutase-1Superoxide Dismutase 2Tumor Necrosis Factor-alphaInterleukin-1betaSOD1 protein, humanSuperoxide DismutaseSuperoxide Dismutase-1Superoxide Dismutase 2Tumor Necrosis Factor-alphabasal cell carcinomacell proliferationinflammatory factorsMalasseziametagenomic sequencingoxidative stress

Identifiers

PMID42708973
PMCPMC13552361

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.