ArticleAnalytical chemistry2026
Thiol-Ene Click-Derived Porous-Layer Open-Tubular Column for Online Purification and Multiplex LC-MS/MS Analysis of Neurotransmitters.
Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A thiol-ene-based porous stationary phase (PLOT-type coating) was developed for online sample cleanup and enrichment coupled to LC-MS/MS for the simultaneous determination of structurally diverse neurotransmitters in biological matrices. The resulting porous thiol-ene functionalized capillary column combines the inherently high permeability of the open-tubular architecture with tailored surface functionality, enabling direct injection and efficient handling of highly polar, low-abundance analytes without derivatization. The method allows multiplexed quantification of serotonin, dopamine, glutamic acid, γ-aminobutyric acid, and reduced glutathione in plasma, cell samples, and brain tissue within a simplified analytical workflow. Compared to conventional off-line protocols, the proposed approach minimizes sample preparation while maintaining high sensitivity and reproducibility, with recoveries ranging from 86% to 100% and matrix effects within 90-104%. The platform demonstrates reliable analytical performance across different biological matrices and is compatible with routine LC-MS/MS instrumentation. Overall, this work establishes the thiol-ene-porous capillary as a viable strategy for integrated sample processing in bioanalysis and expands its application to polar metabolite profiling in complex systems.
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