Evidence map›Paper›PMID 42708611›Full record

ArticleJournal of virology2026

Antagonism of stress granules is key to SARS-CoV-2 infection and pathogenesis.

R Elias Alvarado, Jennifer Chen, Kumari G Lokugamage, Yiyang Zhou, Leah K Estes, Angelica L Morgan, Yani Ahearn, Xiangxue Deng, Lilin Lai, Arian Moayyed and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

R Elias AlvaradoDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Jennifer ChenDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Kumari G LokugamageDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Yiyang ZhouDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0001-8956-3229
Leah K EstesDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Angelica L MorganDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Yani AhearnDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Xiangxue DengDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Lilin LaiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Arian MoayyedDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
William MeyersDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Jessica A PlanteDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Ken S PlanteDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
David H WalkerDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Xuping XieDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0003-0918-016X
Mehul S SutharDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-2686-8380
Bryan A Johnson *Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0002-8999-1255
Vineet D Menachery *Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0001-8803-7606

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viruses must subvert host responses to facilitate successful infection. While most antiviral responses are associated with interferons, stress granules (SGs) are another barrier to viral infection by inducing translation arrest. To combat SG activity, viruses have evolved mechanisms to disrupt formation and disassemble these complexes. Our prior studies identified residues in SARS-CoV-2 NSP3 (Y138/F145) and nucleocapsid (F17) that independently antagonize SG activity. Disrupting these key residues in NSP3 or nucleocapsid attenuated viral replication, but only modestly impacted

Indexed as

coronavirusFXR1G3BP1NSP3nucleocapsidSARS-CoV-2stress granules

Identifiers

PMID42708611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.