Evidence map›Paper›PMID 42708148›Full record

ArticleTheranostics2026

Radiocopper in BCMA-targeted immunotheranostics of myeloma.

Martin Ullrich, Kristof Zarschler, Manja Kubeil, Markus Laube, Jens Pietzsch, Birgit Belter

Abstract read
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Martin UllrichHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Radiopharmaceutical and Chemical Biology, Bautzner Landstrasse 400, D-01328 Dresden, Germany.
Kristof ZarschlerHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Medicinal Radiochemistry, Bautzner Landstrasse 400, D-01328 Dresden, Germany.
Manja KubeilHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Radiopharmaceutical and Chemical Biology, Bautzner Landstrasse 400, D-01328 Dresden, Germany.
Markus LaubeHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Radiopharmaceutical and Chemical Biology, Bautzner Landstrasse 400, D-01328 Dresden, Germany.
Jens PietzschHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Radiopharmaceutical and Chemical Biology, Bautzner Landstrasse 400, D-01328 Dresden, Germany.
Birgit BelterHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Radiopharmaceutical and Chemical Biology, Bautzner Landstrasse 400, D-01328 Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The theranostic potential of copper-64 (PET imaging) and copper-67 (SPECT imaging and therapy) is increasingly recognized. This work investigates the performance of this 'true' matched pair in a preclinical radioimmunotheranostic setting that utilizes experimental monoclonal antibodies (mAbs) directed against B cell maturation antigen (BCMA), a transmembrane glycoprotein that has emerged as a critical target for the treatment of multiple myeloma (MM). Methods: The commercially available BCMA-directed mAbs MAB193 and Vicky-1 were modified with the bispidine N Results: After bioconjugation, both [ Conclusion: The fundamental efficacy of copper-64 and copper-67 in BCMA-targeted immunotheranostics of MM promises both precise PET-based dose planning as well as radioimmunotherapy in combination with highly sensitive SPECT-based dose monitoring, as demonstrated by the theranostic capabilities of [

Indexed as

Antibodies, MonoclonalB-Cell Maturation AntigenCopperCopper RadioisotopesMultiple MyelomaRadioimmunotherapyAnimalsCell Line, TumorFemaleHumansMicePositron-Emission TomographyTomography, Emission-Computed, Single-PhotonAntibodies, MonoclonalB-Cell Maturation AntigenCopperCopper-64Copper-67Copper RadioisotopesTNFRSF17 protein, humanB cell maturation antigenbispidine chelatorscopper-64copper-67multiple myelomasmall animal PETsmall animal SPECTxenograft model

Identifiers

PMID42708148
PMCPMC13549754

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.