Evidence map›Paper›PMID 42708146›Full record

ArticleNeurosurgery practice2026

Stereotactic Radiosurgery for Thalamic Brain Metastases: A Retrospective Analysis and Literature Review.

Ahed H Kattaa, Amit R Persad, Paul M Harary, Rodas Kassu, Muhammad Izhar, Santosh Guru, Amirhossein Akhavan-Sigari, David A Purger, Yusuke S Hori, Louisa Ustrzynski and 8 more

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Article in Neurosurgery practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ahed H KattaaDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.
Amit R PersadDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.
Paul M HararyDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.
Rodas KassuDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.
Muhammad IzharDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.
Santosh GuruDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.
Amirhossein Akhavan-SigariDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.
David A PurgerDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.
Yusuke S HoriDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.
Louisa UstrzynskiDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.
Sara C EmrichDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.
Armine TayagDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.
Xuejun GuDepartment of Radiation Oncology, School of Medicine, Stanford University, Stanford, California, USA.
Lei WangDepartment of Radiation Oncology, School of Medicine, Stanford University, Stanford, California, USA.
Erqi L PollomDepartment of Radiation Oncology, School of Medicine, Stanford University, Stanford, California, USA.
Scott G SoltysDepartment of Radiation Oncology, School of Medicine, Stanford University, Stanford, California, USA.
David J ParkDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.ORCID https://orcid.org/0000-0002-9858-2592
Steven D ChangDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe thalamus, a neural processor and integrator for forebrain activities, is an uncommon site for metastatic lesions. Stereotactic radiosurgery (SRS) has become a noninvasive treatment for brain metastases. This study assesses the efficacy, safety, and outcomes of SRS in patients with thalamic metastases, focusing on local control, overall survival (OS), progression-free survival, neurological outcomes, and treatment response factors.

methodsWe retrospectively reviewed cases of thalamic brain metastases treated with SRS at our institute between 2002 and 2024. A total of 49 lesions from 47 patients were included. Statistical analyses were performed logistic regression, the χ

resultsThe median OS was 18 months (95% CI, 9.4-26.6). The median age at diagnosis was 60 years; 61.7% were female. Primary tumor histology included non-small cell lung cancer (46.8%), breast cancer (14.9%), and small cell lung cancer (10.6%), among others. The median size of metastases was 1.0 cm with a mean volume of 2 cm

conclusionOur results showed sufficient local control after treatment. SRS demonstrates efficacy and safety in managing thalamic metastases, with high local control rates over time, supporting its role as an effective treatment option.

Indexed as

Brain metastasesCNS cancerCyberknife radiosurgeryRadiosurgeryThalamus

Identifiers

PMID42708146
PMCPMC13549586

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.