Evidence map›Paper›PMID 42708133›Full record

ArticleStroke (Hoboken, N.J.)2026

Aspirin Use and the Risk of Symptomatic Hemorrhage in Patients With Cerebral Cavernous Malformations and Ischemic Cerebrovascular Disease.

Jie Wang, Jinyi Tang, Xiudan Bai, Yuming Jiao, Ran Huo, Wenqian Zhang, Yi Wang, Yongbo Yang, Yong Cao

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In one paragraph

Article in Stroke (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jie WangDepartment of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, China (J.W., Y.W., Y.Y.).
Jinyi TangDepartment of Neurosurgery, Beijing Tiantan Hospital (J.T., X.B., Y.J., R.H., W.Z., Y.C.), Capital Medical University, China.ORCID https://orcid.org/0009-0008-0547-3890
Xiudan BaiDepartment of Neurosurgery, Beijing Tiantan Hospital (J.T., X.B., Y.J., R.H., W.Z., Y.C.), Capital Medical University, China.ORCID https://orcid.org/0009-0002-4709-6209
Yuming JiaoDepartment of Neurosurgery, Beijing Tiantan Hospital (J.T., X.B., Y.J., R.H., W.Z., Y.C.), Capital Medical University, China.ORCID https://orcid.org/0000-0001-8351-4602
Ran HuoDepartment of Neurosurgery, Beijing Tiantan Hospital (J.T., X.B., Y.J., R.H., W.Z., Y.C.), Capital Medical University, China.
Wenqian ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital (J.T., X.B., Y.J., R.H., W.Z., Y.C.), Capital Medical University, China.
Yi WangDepartment of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, China (J.W., Y.W., Y.Y.).ORCID https://orcid.org/0000-0002-6779-6758
Yongbo YangDepartment of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, China (J.W., Y.W., Y.Y.).ORCID https://orcid.org/0000-0001-5403-3068
Yong CaoDepartment of Neurosurgery, Beijing Tiantan Hospital (J.T., X.B., Y.J., R.H., W.Z., Y.C.), Capital Medical University, China.ORCID https://orcid.org/0000-0002-8289-1120

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral cavernous malformations (CCMs) are a common cause of spontaneous intracerebral hemorrhage (ICH). However, the association of aspirin with the hemorrhage risk of CCMs remains unclear.

methodsThis retrospective study consecutively enrolled patients with CCMs and asymptomatic or symptomatic ischemic cerebrovascular disease between March 2015 and July 2024. Baseline and follow-up information, including ICH presentation and aspirin use, were recorded. The primary outcome was a CCM-related hemorrhage event, defined as the onset of any new or worsened clinical symptoms caused by overt ICH, confirmed by radiological evidence. Independent factors of symptomatic hemorrhage were analyzed using Cox regression before and after 1:1 propensity score matching.

resultsAmong 259 patients with untreated CCMs, 129 (49.8%) patients took aspirin daily. Over a total follow-up time of 793.0 person-years, new clinical hemorrhage events occurred in 30 (11.6%) patients, including 27 (20.8%) in the nonaspirin group and 3 (2.3%) in the aspirin group. Multivariable Cox analysis revealed that CCM size, developmental venous anomaly, and ICH presentation were associated with a high risk of CCM hemorrhage, whereas aspirin use (hazard ratio, 0.13 [95% CI, 0.03-0.61];

conclusionsAspirin use is associated with a lower risk of symptomatic hemorrhage in patients with CCMs and ischemic cerebrovascular disease. Prospective studies are needed to validate these findings.

Indexed as

aspirincerebral cavernous malformationscerebral hemorrhagepropensity score

Identifiers

PMID42708133
PMCPMC13549612

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.