ArticleInternational journal of women's health2026
Expression and Clinical Significance of the MRPS5 Gene in Uterine Corpus Endometrial Carcinoma: A Comprehensive Study Based on Public Databases.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To examine the expression and clinical implications of the mitochondrial ribosomal protein S5 (MRPS5) gene in uterine corpus endometrial carcinoma (UCEC) using bioinformatics tools. Methods: A comprehensive analysis was performed utilizing databases such as SANGERBOX, XIANTAO BIOINFORMATICS TOOL, UALCAN, and STRING. Expression levels of MRPS5 in UCEC were validated through Western blotting (WB) and real-time quantitative PCR (RT-qPCR) to determine its clinical relevance. Results: MRPS5 expression was significantly elevated in UCEC patients (n=546) compared to normal tissues (n=35), Conclusion: MRPS5 gene is highly expressed in most cases of UCEC, and is correlated with disease onset, progression, and adverse prognosis, suggesting its potential as a valuable biomarker for diagnosis, treatment, and prognosis of UCEC.
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