ReviewJournal of pain research2026
Association Between Fibromyalgia and Lower Urinary Tract Pain and Storage Symptoms in Women: A Systematic Review and Meta‑analysis.
Review in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Fibromyalgia (FM), a chronic centralized pain syndrome, has been associated with lower urinary tract pain and lower urinary tract symptoms (LUTS) in women, but quantitative evidence remains limited. We searched PubMed/MEDLINE, Embase, Web of Science Core Collection, and CINAHL from January 1990 to December 2025 for observational studies. Fourteen studies involving 17,139 women were included. Random-effects meta-analysis showed increased odds of lower urinary tract pain (OR = 2.92, 95% CI: 1.41-6.06) and lower urinary tract symptoms (OR = 2.83, 95% CI: 1.98-4.03), but the certainty of evidence was very low. For lower urinary tract pain, the association was concentrated in studies using validated interstitial cystitis/painful bladder syndrome definitions; the clinician-based FM subgroup yielded a more conservative estimate (OR = 1.45, 95% CI: 1.15-1.83), whereas the larger self-reported estimate (OR = 5.84, 95% CI: 2.16-15.79) may have inflated the overall pooled estimate. The overall LUTS association appeared to be driven predominantly by urgency-related storage symptoms, including overactive bladder (OR = 2.65, 95% CI: 1.88-3.74) and urge urinary incontinence (OR = 2.95, 95% CI: 1.05-8.28); no significant association was found for stress urinary incontinence (OR = 1.00, 95% CI: 0.63-1.59). Heterogeneity was substantial for both primary outcomes (
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