ArticleERJ open research2026
Immunological biomarkers predict pulmonary and nodal, but not cardiac positron emission tomography-assessed sarcoidosis activity.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sarcoidosis is a systemic granulomatous disease with highly variable clinical manifestations and organ involvement. Symptoms are often unspecific or absent and may not reflect true inflammatory burden, increasing the risk of delayed detection of organ damage. Reliable assessment of disease activity is therefore essential for treatment guidance. We aimed to investigate the correlation and predictive performance of circulating biomarkers with systemic inflammatory activity as assessed by Methods: We conducted a retrospective cohort study including 180 patients with systemic sarcoidosis who underwent paired Results: TNF-α, sIL-2R and neopterin consistently showed significant correlation with PET activity already for moderate inflammatory activity (activity-quartile 2-3 Conclusion: Immunological biomarkers such as TNF-α, sIL-2R and neopterin outperform traditional markers such as CRP and ACE activity, and should be considered in the assessment of systemic sarcoidosis activity at diagnosis and follow-up. Since no biomarker was able to predict cardiac inflammatory activity, imaging techniques such as magnetic resonance imaging and
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