ArticleIndian journal of dermatology
Detection of Dermatophytes in Subclinically Involved Nails by Polymerase Chain Reaction in Patients with Skin Dermatophytosis: A Prospective Observational Study.
Article in Indian journal of dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Context: Patients with skin dermatophytosis can have subclinical dermatophytes in the nails, which can easily be missed on clinical examination. Dermatophytes may not be isolated from normal-appearing nails by KOH and culture, where it can serve as a reservoir for recurrent infection. Detection can be made by polymerase chain reaction (PCR), a more sensitive and faster technique. Aims: To detect the presence of dermatophytes in clinically unaffected nails by PCR in patients with skin dermatophytosis and to evaluate the diagnostic performance of KOH, culture, and PCR in detecting subclinical nail involvement. Materials and Methods: In this prospective observational study, 120 patients with skin KOH positivity had their nail clippings collected and sent for KOH, PCR, and culture. Results were tabulated, and statistical analysis was done. Results: Out of 120 patients, nail KOH revealed that 39 patients (32.5%) tested positive for dermatophytes, while 81 (67.5%) tested negative. Nail culture on Sabouraud dextrose agar (SDA) and dermatophyte test medium (DTM) showed dermatophyte growth in 44 patients: Conclusion: In patients with dermatophyte infection, nail PCR can detect subclinical infection in the nail, which may serve as a reservoir for ongoing infection and recurrence.
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