Evidence map›Paper›PMID 42707799›Full record

ArticleStroke (Hoboken, N.J.)2026

Early Reperfusion in Basilar Artery Occlusion Stroke Managed With Tenecteplase Versus Alteplase Before Endovascular Treatment.

Dylan N Wolman, Rahul R Karamchandani, Kwadwo Darko, Tyler M Bielinski, Nitin Goyal, Jeremy B Rhoten, Mahesh V Jayaraman, Christian T Sidebottom, Bradley A Gross, Alhamza R Al-Bayati and 29 more

Abstract read
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In one paragraph

Article in Stroke (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Dylan N WolmanDepartment of Radiology (D.N.W., M.V.J.), Warren Alpert School of Medicine at Brown University, Rhode Island Hospital, Providence.ORCID https://orcid.org/0000-0002-5012-1690
Rahul R KaramchandaniDepartment of Neurology, Wake Forest University School of Medicine, Neurosciences Institute, Advocate Health, Charlotte, NC (R.R.K., J.B.R.).ORCID https://orcid.org/0000-0002-2111-5523
Kwadwo DarkoDepartment of Neurosurgery, Geisinger, Danville, PA (K.D., C.M.S., P.H.).ORCID https://orcid.org/0000-0002-7734-195X
Tyler M BielinskiGeisinger College of Health Sciences, Scranton, PA (T.M.B.).
Nitin GoyalDepartment of Neurology, Semmes Murphey Clinic, University of Tennessee Health Sciences Center, Memphis (N.G., C.T.S.).ORCID https://orcid.org/0000-0002-4699-0922
Jeremy B RhotenDepartment of Neurology, Wake Forest University School of Medicine, Neurosciences Institute, Advocate Health, Charlotte, NC (R.R.K., J.B.R.).ORCID https://orcid.org/0000-0002-7753-2158
Mahesh V JayaramanDepartment of Radiology (D.N.W., M.V.J.), Warren Alpert School of Medicine at Brown University, Rhode Island Hospital, Providence.
Christian T SidebottomDepartment of Neurology, Semmes Murphey Clinic, University of Tennessee Health Sciences Center, Memphis (N.G., C.T.S.).
Bradley A GrossDepartments of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, PA (B.A.G., A.R.A.-B., M.F.D., R.G.N.).ORCID https://orcid.org/0000-0002-6999-7967
Alhamza R Al-BayatiDepartments of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, PA (B.A.G., A.R.A.-B., M.F.D., R.G.N.).ORCID https://orcid.org/0000-0001-8103-1930
Mohamed F DoheimDepartments of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, PA (B.A.G., A.R.A.-B., M.F.D., R.G.N.).ORCID https://orcid.org/0000-0001-8279-5078
Matthew K TobinDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis (M.K.T., A.C., B.N.B.).ORCID https://orcid.org/0000-0001-5717-5133
Anoop ChinthalaDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis (M.K.T., A.C., B.N.B.).ORCID https://orcid.org/0000-0002-6065-1177
Avi GajjarDepartment of Neurosurgery, Albany Medical Center, NY (A.G., A.R.P.).ORCID https://orcid.org/0000-0003-3686-9413
Justin MascitelliDepartment of Neurosurgery, University of Texas Health Science Center at San Antonio (J.M., M.R.W.).
Matthew R WebbDepartment of Neurosurgery, University of Texas Health Science Center at San Antonio (J.M., M.R.W.).
Jan-Karl BurkhardtDepartment of Neurosurgery, University of Pennsylvania Health System, Philadelphia (J.-K.B., K.W.S., V.S.).ORCID https://orcid.org/0000-0001-8381-0313
Kyle W ScottDepartment of Neurosurgery, University of Pennsylvania Health System, Philadelphia (J.-K.B., K.W.S., V.S.).
Visish SrinivasanDepartment of Neurosurgery, University of Pennsylvania Health System, Philadelphia (J.-K.B., K.W.S., V.S.).ORCID https://orcid.org/0000-0001-7673-6805
Daniel TonettiDepartment of Neurological Surgery, Cooper University Health Care, Camden, NJ (D.T., M.K.).ORCID https://orcid.org/0000-0002-9258-1820
Manisha KoneruDepartment of Neurological Surgery, Cooper University Health Care, Camden, NJ (D.T., M.K.).ORCID https://orcid.org/0000-0001-5012-6793
David J AltschulDepartment of Neurological Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (D.J.A., D.V.).ORCID https://orcid.org/0000-0002-5130-1378
Dhrumhil VaishnavDepartment of Neurological Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (D.J.A., D.V.).ORCID https://orcid.org/0000-0002-0037-6628
Sumeet MultaniMain Line Health-Jefferson Neurosurgery, Paoli, PA (S.M., T.T.).
Thana TheofanisMain Line Health-Jefferson Neurosurgery, Paoli, PA (S.M., T.T.).
William J AresDepartment of Neurosurgery, Northshore University HealthSystem, Evanston, IL (W.J.A., J.Y.S.).
Je Yeong SoneDepartment of Neurosurgery, Northshore University HealthSystem, Evanston, IL (W.J.A., J.Y.S.).
Ramin ZandDepartment of Neurology, College of Medicine, The Pennsylvania State University, Hershey (R.Z., S.B.).ORCID https://orcid.org/0000-0002-9477-0094
Sasan BahramiDepartment of Neurology, College of Medicine, The Pennsylvania State University, Hershey (R.Z., S.B.).ORCID https://orcid.org/0009-0009-4447-501X
Jiang LiDepartment of Molecular and Functional Genomics, Weis Center for Research, Geisinger, Danville, PA (J.L.).ORCID https://orcid.org/0000-0002-7006-1285
Gary DefilippCharlotte Radiology, Advocate Health, NC (G.D.).
Dale StrongInformation and Analytics Services, Advocate Health, Charlotte, NC (D.S.).ORCID https://orcid.org/0000-0003-4059-0319
Radmehr TorabiDepartment of Neurosurgery (R.T., K.M.), Warren Alpert School of Medicine at Brown University, Rhode Island Hospital, Providence.ORCID https://orcid.org/0000-0003-4764-4754
Krisztina MoldovanDepartment of Neurosurgery (R.T., K.M.), Warren Alpert School of Medicine at Brown University, Rhode Island Hospital, Providence.
Clemens M SchirmerDepartment of Neurosurgery, Geisinger, Danville, PA (K.D., C.M.S., P.H.).ORCID https://orcid.org/0000-0003-1743-8781
Raul G NogueiraDepartments of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, PA (B.A.G., A.R.A.-B., M.F.D., R.G.N.).ORCID https://orcid.org/0000-0003-4532-153X
Bradley N BohnstedtDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis (M.K.T., A.C., B.N.B.).ORCID https://orcid.org/0000-0001-6254-2313
Alexandra R PaulDepartment of Neurosurgery, Albany Medical Center, NY (A.G., A.R.P.).ORCID https://orcid.org/0000-0002-8315-5870
Philipp HendrixDepartment of Neurosurgery, Geisinger, Danville, PA (K.D., C.M.S., P.H.).ORCID https://orcid.org/0000-0003-0017-5049

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTimely reperfusion is a critical determinant of favorable outcomes in basilar artery occlusion (BAO) stroke. We aimed to examine whether the choice of thrombolytic agent predicts early reperfusion (ER) in BAO stroke managed with tenecteplase versus alteplase before endovascular treatment.

methodsThis was a retrospective, multicenter US cohort of consecutive patients with BAO from 14 stroke centers treated with tenecteplase or alteplase within 4.5 hours of last known well before endovascular treatment. The primary end point was ER, defined as angiographic ER (expanded Thrombolysis in Cerebral Infarction grade 2b to 3 on the first diagnostic angiogram), or clinical ER, defined as substantial neurological improvement precluding endovascular treatment and a good functional outcome (modified Rankin Scale score 0-3).

resultsAmong 163 patients with BAO and a median last known well-to-needle time of 135 minutes (interquartile range, 100-193) and last known well-to-puncture time of 228 minutes (interquartile range, 166-307), ER was observed in 27 (16.6%) patients. Rates of ER were comparable between tenecteplase (14/75, 18.7%) and alteplase (13/88, 14.8%; adjusted odds ratio, 1.082 [95% CI, 0.444-2.631];

conclusionsIn BAO treated within 4.5 hours of last known well, tenecteplase and alteplase produced comparable early reperfusion rates. Achieving ER did not modify the association between thrombolytic agent and good functional outcome, consistent with rapid thrombectomy in patients with no ER.

Indexed as

basilar arterycerebral infarctionpuncturesreperfusionstroke

Identifiers

PMID42707799
PMCPMC13549654

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.