Evidence map›Paper›PMID 42707779›Full record

ArticleStroke (Hoboken, N.J.)2026

Diving MCA and First-Pass Effect: A Subgroup Analysis From the ARISE II Study.

Yazan Ashouri, Mohammad AlMajali, Amit Chaudhari, Tommy Andersson, Jeffrey L Saver, Alex Bou Chebl, Saif Bushnaq, Nicholas Liaw, Hormozd Bozorgchami, Marc Ribo and 17 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02488915 (ARISE II), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02488915 nacompletednot on this map

ARISE II (Analysis of Revascularization in Ischemic Stroke With EmboTrap) Study

TypeinterventionalSponsorNeuravi Inc.Ran2015 to 2017Enrolled228ConditionsStroke, IschemiaArmsEmboTrap® Revascularization Device
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Yazan AshouriDepartment of Neuroscience, Mercy Health St Vincent Medical Center, Toledo, OH (Y.A., M.A., A.C., E.L., O.O.Z.).ORCID https://orcid.org/0000-0003-3380-434X
Mohammad AlMajaliDepartment of Neuroscience, Mercy Health St Vincent Medical Center, Toledo, OH (Y.A., M.A., A.C., E.L., O.O.Z.).ORCID https://orcid.org/0000-0001-5051-6687
Amit ChaudhariDepartment of Neuroscience, Mercy Health St Vincent Medical Center, Toledo, OH (Y.A., M.A., A.C., E.L., O.O.Z.).
Tommy AnderssonAZ Groeninge, Kortrijk, Belgium (T.A., O.F.).ORCID https://orcid.org/0000-0001-8202-7829
Jeffrey L SaverDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles (J.L.S.).ORCID https://orcid.org/0000-0001-9141-2251
Alex Bou CheblDepartment of Neurology, Henry Ford Medical Center, Detroit, MI (A.B.C.).ORCID https://orcid.org/0000-0002-2803-1779
Saif BushnaqDepartment of Neurology, Texas Tech University, Lubbock (S.B.).
Nicholas LiawVascular Neurology Las Vegas, NV (N.L.).
Hormozd BozorgchamiOregon Health and Science University Hospital, Portland (H.B., W.M.C.).
Marc RiboDepartment of Neuroradiology, Vall d'Hebron University Hospital, Barcelona, Spain (M.R., A.T.).ORCID https://orcid.org/0000-0001-9242-043X
Varun ChaubalDepartment of Neuro Endovascular Surgery, HCA Houston Healthcare Kingwood, TX (V.C.).ORCID https://orcid.org/0009-0003-5354-1636
Heinrich P MattleDepartment of Neurology, Inselspital, University of Bern, Switzerland (H.P.M.).ORCID https://orcid.org/0000-0001-7968-1731
René ChapotDepartment of Radiology and Neuroradiology, Alfried Krupp Krankenhaus, Essen, Germany (R.C., H.N.).ORCID https://orcid.org/0000-0002-2584-8361
Ana Paula NarataCentre Hospitalier Régional Universitaire, Hôpitaux de Tours, France (A.P.N.).
Olivier FrançoisAZ Groeninge, Kortrijk, Belgium (T.A., O.F.).ORCID https://orcid.org/0000-0001-5825-8897
Ashutosh P JadhavDepartment of Neurology, University of Pittsburgh Medical Center, PA (A.P.J., T.G.J.).ORCID https://orcid.org/0000-0002-9454-0678
Jonathan A GrossbergDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA (J.A.G., R.G.N.).ORCID https://orcid.org/0000-0002-1152-8826
Christian Heiner RiedelUniversitätsklinikum Schleswig-Holstein, Kiel Campus, Germany (C.H.R.).
Alejandro TomaselloDepartment of Neuroradiology, Vall d'Hebron University Hospital, Barcelona, Spain (M.R., A.T.).ORCID https://orcid.org/0000-0002-6736-1535
Wayne M ClarkOregon Health and Science University Hospital, Portland (H.B., W.M.C.).ORCID https://orcid.org/0000-0001-7901-5659
Hannes NordmeyerDepartment of Radiology and Neuroradiology, Alfried Krupp Krankenhaus, Essen, Germany (R.C., H.N.).
Eugene LinDepartment of Neuroscience, Mercy Health St Vincent Medical Center, Toledo, OH (Y.A., M.A., A.C., E.L., O.O.Z.).ORCID https://orcid.org/0000-0002-0191-1602
Raul G NogueiraDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA (J.A.G., R.G.N.).ORCID https://orcid.org/0000-0003-4532-153X
Albert J YooDepartment of Interventional Radiology, Texas Stroke Institute, Dallas-Fort Worth, (A.J.Y.).ORCID https://orcid.org/0000-0002-7657-142X
Tudor G JovinDepartment of Neurology, University of Pittsburgh Medical Center, PA (A.P.J., T.G.J.).ORCID https://orcid.org/0000-0002-2619-6975
Adnan H SiddiquiDepartment of Neurosurgery, University of Buffalo, NY (A.H.S.).ORCID https://orcid.org/0000-0002-9519-0059
Osama O ZaidatDepartment of Neuroscience, Mercy Health St Vincent Medical Center, Toledo, OH (Y.A., M.A., A.C., E.L., O.O.Z.).ORCID https://orcid.org/0000-0003-4881-4698

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of internal carotid artery tortuosity on achieving first-pass effect in mechanical thrombectomy has been described; however, middle cerebral artery (MCA) tortuosity remains understudied. We investigated the association of MCA tortuosity with radiographic and functional outcome using quantitative and qualitative measures.

methodsThe ARISE II study (Analysis of Revascularization in Ischemic Stroke With EmboTrap) was used to identify patients with anterior circulation stroke. MCA tortuosity was calculated using the Inflection Count Metric by 2 readers blinded to the angiographic/clinical outcomes. The total cohort was trichotomized into 3 groups (A, B, and C) based on M1 tortuosity tertiles, with group A representing the lowest tertile and group C representing the highest tertile. The primary efficacy end point was the achievement of first-pass expanded Thrombolysis in Cerebral Ischemia reperfusion ≥2c. A good functional outcome was defined as a 90-day modified Rankin Scale score of 0 to 2. Baseline and procedural data were compared between groups.

resultsA total of 168 patients with M1 or M2 occlusion and measurable MCA tortuosity were identified. Patients in group C were more likely to have renal disease and hyperlipidemia, whereas patients in group A were more likely to have hypertension (

conclusionsPatients with higher MCA tortuosity were less likely to achieve first-pass effect, successful reperfusion, and good functional outcome at 90 days postmechanical thrombectomy for acute ischemic stroke. REGISTRATION: URL: http://clinicaltrials.gov; Unique identifier: NCT02488915.

Indexed as

endovascular proceduresischemic strokemiddle cerebral arteryreperfusionthrombectomy

Identifiers

PMID42707779
PMCPMC13549569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.