ArticleCancer management and research2026
Clinicopathological Significance of Ultrasound Risk Features and the Taller-Than-Wide Sign for Tumor Advancement in Differentiated Thyroid Cancer: A Single-Center Analysis.
Article in Cancer management and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Ultrasound (US) imaging plays a pivotal role in the preoperative assessment of thyroid cancer (TC). Suspicious US features, including hypoechogenicity, microcalcifications, high vascularity, irregular shape, irregular margins, and the taller-than-wide (TTW) sign, are widely used for preoperative risk stratification of thyroid nodules. This study aimed to investigate the associations between preoperative US features and histopathological indicators of tumor advancement in differentiated thyroid cancer (DTC). Patients and Methods: We conducted a retrospective analysis of 665 patients with DTC who were treated between 2008 and 2024. Preoperative US features, including hypoechogenicity, microcalcifications, high vascularity, irregular shape, irregular margins, and the TTW sign, were correlated with extrathyroidal extension (ETE) and lymph node metastases (LNM). Associations were evaluated using Pearson's χ Results: All analyzed US features were significantly associated with histopathological indicators of tumor advancement (p < 0.05). Of all evaluated conventional US features, the strongest associations were observed between microcalcifications and ETE, and between high vascularity and LNM (Cramér's V = 0.32 and 0.38, respectively). The TTW sign was significantly associated with ETE (OR = 2.96, 95% CI: 1.73-5.07) and LNM (OR = 9.07, 95% CI: 5.07-16.24). Conclusion: Among US features, the TTW sign demonstrated particularly strong associations with histopathological indicators of tumor advancement, especially LNM. These findings support the potential value of comprehensive preoperative assessment of US features and warrant further prospective studies with multivariable modelling to better define the role of the TTW sign in preoperative risk stratification of DTC.
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