Evidence map›Paper›PMID 42707684›Full record

ArticleJournal of inflammation research2026

Association of CD16

Xianglan Yao, Heather L Teague, Lauren E Knabe, Raquel Santana da Cruz, Trenton Williams, Merte Lemma Woldehanna, Ernest Evans, Amir Hobson, Jared D Wilkinson, Cumhur Yusuf Demirkale and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xianglan YaoCritical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Heather L TeagueCritical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Lauren E KnabeCritical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Raquel Santana da CruzCritical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Trenton WilliamsCritical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Merte Lemma WoldehannaAdvanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.
Ernest EvansAdvanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.
Amir HobsonAdvanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.
Jared D WilkinsonAdvanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.
Cumhur Yusuf DemirkaleCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Steven D NathanAdvanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.
Christopher KingAdvanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.
Jeffrey R StrichCritical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5671-1130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sepsis is a global health priority that leads to significant morbidity and mortality. Therefore, there is an urgent need to better understand sepsis pathogenesis to inform diagnosis, prognosis, and identify novel host-directed therapeutics. Methods: Flow cytometry was performed on 35 sepsis patients and 18 healthy controls to characterize neutrophils and neutrophil subsets and their association with clinical outcomes. Additionally, purified neutrophils from 20 sepsis patients were stimulated with lipopolysaccharide (LPS), with and without R406 treatment, to assess changes in neutrophil populations and the impact of spleen tyrosine kinase (SYK) inhibition. Results: We found that patients with sepsis have increased levels of circulating CD16 Conclusion: These data suggest that CD16

Indexed as

neutrophilssepsisspleen tyrosine kinase

Identifiers

PMID42707684
PMCPMC13549185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.