Evidence map›Paper›PMID 42707658›Full record

ArticleAdvances in urology2026

Klotho G-395A Polymorphism as a Risk Factor for Atrial Fibrillation in Patients on Maintenance Hemodialysis.

Ying Zhang, Xiangxiang Wang, XiaoXuan Su, Zhixiang Bian, Shunjie Chen

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Article in Advances in urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ying ZhangNephrology Department, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China, tongji.edu.cn.
Xiangxiang WangNephrology Department, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China, tongji.edu.cn.
XiaoXuan SuNephrology Department, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China, tongji.edu.cn.
Zhixiang BianNephrology Department, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China, tongji.edu.cn.ORCID https://orcid.org/0009-0005-1963-7735
Shunjie ChenNephrology Department, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China, tongji.edu.cn.ORCID https://orcid.org/0009-0005-2464-9538

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the relationship between atrial fibrillation and the Klotho G-395A polymorphism in patients on maintenance hemodialysis (MHD). Methods: The study included 120 MHD patients (persistent atrial fibrillation, Results: Three genotypes of Klotho G-395A, namely, GG, GA, and AA, were detected. The frequencies of the GA/AA genotypes and A allelic genes were significantly higher in the MHD patients than in the healthy controls, and these genotypes were associated with both atrial fibrillation and persistent atrial fibrillation. Furthermore, serum sKl, serum iFGF23, and left artery diameter were significantly associated with atrial fibrillation and also showed significant differences between the persistent and paroxysmal atrial fibrillation groups. The serum sKl level was negatively correlated with serum FGF23 level and the left atrium diameter, while the serum FGF23 level was positively correlated with the left atrium diameter. The incidence of atrial fibrillation and left atrium diameter was significantly higher in those with the GA/AA genotype than in those with the GG genotype, while the serum sKl levels were significantly lower. The GA/AA genotype was associated with a 5.444 times higher likelihood of atrial fibrillation than the GG genotype. Conclusions: The A allele of Klotho G-395A may be a risk marker of atrial fibrillation in MHD patients. Moreover, sKl deficiency may contribute to the early development of atrial fibrillation in MHD patients.

Indexed as

atrial fibrillationintact fibroblast growth factor 23klotho G-395Aleft atrial diametermaintenance hemodialysissoluble klotho protein

Identifiers

PMID42707658
PMCPMC13547953

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