ArticleFrontiers in cardiovascular medicine2026
Coronary artery calcium and thoracic aortic calcification on non-ECG-gated chest CT in a large community-based cohort of Chinese men and women.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Age-Dependent Efficacy of Incidental Coronary Artery Calcium on Pre-CAG Chest CT: Potentially Missed Prevention Opportunities in Chinese Population.Journal of cardiovascular development and disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: Non-ECG-gated chest CT frequently identifies coronary artery calcification (CAC) and thoracic aortic calcification (TAC), but age- and sex-specific thresholds remain unclear in Chinese communities. The ACC/AHA guideline recommends statins for those with CAC ≥75th percentile1. In subgroups with CAC positivity rate ≤25%, any detectable CAC corresponds to the ≥75th percentile. We aimed to determine precise sex-specific age thresholds using single-year stratification for opportunistic cardiovascular risk stratification. Methods: A total of 42 363 participants aged 1-105 years (mean age: 56.9 ± 17.3 years; 52.0% male) who underwent non‑ECG‑gated chest CT from 2023 to 2025 were enrolled in this retrospective study. CAC and TAC were visually evaluated as binary (present/absent) variables. Single‑year stratification was applied to calculate key age thresholds corresponding to 25%, 50%, and 75% positivity rates of CAC and TAC. Distributions of isolated CAC, isolated TAC, and combined vascular calcification were compared between men and women. Results: The ages at which CAC positivity reached 25%, 50%, and 75% were 48, 57, and 70 years for men versus 58, 67, and 76 years for women. Corresponding TAC threshold ages were 57, 60, and 71 years in men and 60, 67, and 78 years in women; TAC showed strong age dependence with modest sex‑related differences. The inflection age for CAC positivity exceeding 25% was approximately 58 years in women, around 10 years later than that observed in men. Isolated CAC was more frequent among men, while isolated TAC predominated in women; combined calcification became the dominant phenotype with increasing age. Conclusion: In male aged <48 years and women aged <58 years, CAC detected on non-gated chest CT may warrant statin initiation, providing additional cost-free opportunistic risk stratification beyond current guideline recommendations. Moreover, CAC-negative individuals aged <70 years in men and <76 years in women are likely to have a favorable cardiovascular prognosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.