Evidence map›Paper›PMID 42707557›Full record

ArticleERJ open research2026

Computed tomography-derived pulmonary blood volume distribution may be modifiable in asthma.

Anusha A Mappanasingam, Yonni Friedlander, Ekamdeep Sandhu, Ashutosh Thakar, Nandhitha Ragunayakam, Nisarg Radadia, Melanie Kjarsgaard, John E McDonough, Carmen Venegas Garrido, Nathan Hambly and 3 more

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Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anusha A MappanasingamDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0009-0009-0902-132X
Yonni FriedlanderFirestone Institute for Respiratory Health, Hamilton, ON, Canada.
Ekamdeep SandhuDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada.
Ashutosh ThakarDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada.
Nandhitha RagunayakamDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada.
Nisarg RadadiaDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada.
Melanie KjarsgaardDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada.
John E McDonoughDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0000-0003-2497-0258
Carmen Venegas GarridoDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada.
Nathan HamblyDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada.
Manali MukherjeeDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0000-0002-7924-7211
Parameswaran NairDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada.
Sarah SvenningsenDepartment of Medicine, Division of Respirology, McMaster University, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A smaller relative volume of the peripheral pulmonary vasculature in asthma, termed "vascular pruning", has been linked to greater disease severity, exacerbations, and airflow obstruction. It is not known whether this is reversible. Therefore, the study objective was to determine whether "loss" of computed tomography (CT) measures of peripheral pulmonary vasculature is a modifiable feature of asthma pathophysiology by assessing its response to dupilumab. Methods: 27 adults with moderate-to-severe asthma received dupilumab (n=19) or placebo (n=8) every 2 weeks for 16 weeks. Chest CT scans acquired at baseline and follow-up were analysed to quantify pulmonary blood vessel volumes categorised by cross-sectional area (≤5 mm Results: Following dupilumab treatment (but not placebo), BV5% increased by 1.0% (95% CI -0.2% to 4.5%, p=0.02) and BV10% decreased by 1.0% (95% CI -3.6% to 0.7%, p=0.03). The between-group difference in median change was 3.0% for BV5% (95% CI 0.6% to 5.5%; p=0.008) and -3.0% for BV10% (95% CI -5.2% to -1.0%; p=0.007). In dupilumab-treated participants, the increase in BV5% and decrease in BV10% was associated with improved Asthma Control Questionnaire-5, forced expiratory volume in 1 s, fraction of exhaled nitric oxide and sputum eosinophil percentage (all p<0.05). Conclusion: A redistribution of pulmonary blood volume toward smaller vessels was observed following dupilumab, suggesting that CT-derived pulmonary vascular measurements may be modifiable in asthma.

Identifiers

PMID42707557
PMCPMC13548440

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.