ArticleFrontiers in chemistry2026
A type of magnetically induced self-assembled electrochemical aptamer nanobiosensor for ultrasensitive detection of hypoxia-inducible factor 1α protein.
Article in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hypoxia-inducible factor 1α (HIF-1α) protein has been identified as an aggressive malignant phenotype marker for numerous tumors; therefore, the detection of HIF-1α has become increasingly significant. Methods: In this work, we developed a type of magnetically induced self-assembled electrochemical aptamer nanobiosensor for detecting HIF-1α protein. This nanobiosensor utilized the magnetism of hydrothermal-calcination-synthesized α-ferric oxide/ferriferrous oxide (α-Fe Results: The nanobiosensor revealed a favorable linear relation in the range of 0.1-1,000 ng/mL with a variance R Conclusion: In this study, we developed a magnetically induced self-assembled electrochemical aptamer nanobiosensor for ultrasensitive detection of HIF-1α protein. The nanosensor delivers outstanding analytical performance with a facile assay strategy suitable for point-of-care testing, suggesting its promising prospects for clinical tests.
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