Evidence map›Paper›PMID 42707502›Full record

ArticleFrontiers in immunology2026

Preoperative immunonutrition as a strategy for reducing oxidative stress and inflammation in pancreatic ductal adenocarcinoma.

Przemysław Kostro, Blanka Wolszczak-Biedrzycka, Edyta Kostro, Joanna Matowicka-Karna, Zbigniew Kamocki, Cezary Pawlukianiec, Mateusz Maciejczyk, Anna Zalewska, Justyna Dorf

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Przemysław KostroDepartment of Thoracic Surgery, Medical University of Bialystok, Bialystok, Poland.
Blanka Wolszczak-BiedrzyckaDepartment of Psychology and Sociology of Health and Public Health, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Edyta KostroDepartment of Conservative Dentistry, Medical University of Bialystok, Bialystok, Poland.
Joanna Matowicka-KarnaDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland.
Zbigniew Kamocki2nd Clinical Department of General and Gastroenterological Surgery, Medical University of Bialystok, Bialystok, Poland.
Cezary PawlukianiecStudents Scientific Club "Biochemistry of Lifestyle Diseases" at the Department of Hygiene, Epidemiology and Environmental Health, Medical University of Bialystok, Bialystok, Poland.
Mateusz MaciejczykDepartment of Hygiene, Epidemiology and Environmental Health, Medical University of Bialystok, Bialystok, Poland.
Anna ZalewskaExperimental Dentistry Laboratory, Medical University of Bialystok, Bialystok, Poland.
Justyna DorfDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The aim of this study was to evaluate the effect of preoperative immunonutrition (IMN) on oxidative stress parameters and inflammatory cytokine concentrations in patients with pancreatic ductal adenocarcinoma (PDAC) undergoing surgical resection. Methods: The study included 52 patients with PDAC, who were divided into two groups: group 1 (n = 26), which received an immunonutrition formula (Impact Oral Results: Patients with PDAC exhibited significantly higher levels of oxidative stress and lower antioxidant potential than the control group. The redox balance was significantly improved, and the concentrations of pro-inflammatory cytokines (IL1α, IL1β, and IL6) decreased after seven days of immunonutrition. However, surgery led to a rapid increase in oxidative stress in both study groups. Discussion: Preoperative immunonutrition is an effective strategy for alleviating oxidative stress and the systemic inflammatory response in patients with PDAC, thereby improving preoperative preparation for surgical resection, which could play a key role in postoperative recovery in this patient population.

Indexed as

Carcinoma, Pancreatic DuctalInflammationOxidative StressPancreatic NeoplasmsPreoperative CareAgedAntioxidantsCytokinesFemaleHumansImmunonutrition DietMaleMiddle AgedAntioxidantsCytokinesbiomarkerscytokinesimmunonutritionoxidative stresspancreatic ductal adenocarcinomaredox balance

Identifiers

PMID42707502
PMCPMC13547478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.