ArticleRSC advances2026
Ir/Rh-catalyzed hydrogenation of squalene: access to stereoregular squalane.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Catalytic stereoselective hydrogenation of unfunctionalized polyenes remains a major challenge because multiple stereogenic centers must be generated in the absence of directing groups. Here we investigate squalene, a flexible hydrocarbon containing six isolated trisubstituted double bonds, as a demanding substrate for assessing stereochemical bias in the complete hydrogenation of an unfunctionalized polyene. Evaluation of Rh- and Ir-based homogeneous catalysts identified one Ir-P,N complex that promotes complete conversion to squalane while inducing a highly non-statistical diastereomeric distribution, reaching up to 90% d.e. The stereochemical outcome was quantified directly by
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