ArticleFrontiers in surgery2026
Nutritional supplementation is associated with improved wound reduction during negative pressure wound therapy in complex wounds: a retrospective cohort study.
Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Negative pressure wound therapy (NPWT) is central to the management of complex wounds, but wound contraction and granulation require adequate metabolic substrate. We evaluated the association between nutritional supplementation and wound healing outcomes in patients treated with NPWT. Methods: This retrospective cohort study included 48 adults who underwent negative pressure wound therapy for complex wounds. Patients were grouped according to receipt of nutritional supplementation. The primary outcome was absence of wound reduction during follow-up. Results: Nutritional supplementation was provided to 24 patients, while 18 received no supplementation. Absence of wound reduction was less frequent with supplementation (2/24 [8.3%] vs. 8/18 [44.4%]; OR 0.114, exact 95% CI 0.011-0.750; Fisher exact Conclusion: Nutritional supplementation was associated with a more favorable local wound trajectory during negative pressure wound therapy, despite no measurable reduction in systemic endpoints. These findings suggest that nutrition can act where negative pressure wound therapy acts first: at the wound bed.
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