ArticleChemical science2026
On-resin Heck coupling enables small-molecule ligand discovery with covalent peptide-encoded libraries.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heck coupling remains challenging in solid-phase peptide synthesis (SPPS) and diversification of combinatorial small-molecule libraries. The intermolecular Heck reaction has not yet been implemented in SPPS, owing to the lack of effective catalysts achieving broad substrate scopes on resin-bound peptides. Peptide-encoded libraries (PELs) enable high-throughput identification of small-molecule ligands to protein targets and allow access to structurally diverse chemotypes. Here, we introduce a covalent PEL (coPEL) platform that incorporates on-resin Heck coupling to derivatize cysteine-reactive scaffolds during solid-phase library synthesis. We leverage the specific reactivity of palladium catalysts derived from
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.