ReviewFrontiers in pharmacology2026
Anti-cancer effects of plant extracts in head and neck squamous cell carcinoma.
Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current treatments for head and neck squamous cell carcinoma (HNSCC) often encounter difficulties such as local tumor recurrence, distant metastasis, drug resistance, and significant toxic side effects. Plant extracts have become important resources for the development of anti-HNSCC drugs due to their multi-target action mechanisms, abundance of bioactive components, reversal of drug resistance, and high selectivity/low toxicity. The challenges faced by plant extracts during anti-cancer clinical translation include low bioavailability, unclear mechanisms of action, complex components, and difficulties in standardization. This review systematically summarizes the latest research progress on the anti-cancer effects of plant extracts in HNSCC and their regulatory signaling pathways. Various plant extracts, such as resveratrol, curcumin, quercetin, and anthocyanins, have anti-HNSCC effects, including inducing apoptosis, inhibiting proliferation, blocking metastasis, and reversing chemoresistance. The key underlying molecular events are primarily mediated by the PI3K/AKT/mTOR, MAPK, and JAK/STAT3 cascades. Future research directions for plant extracts in combating HNSCC include developing intelligent nano-drug delivery systems, integrating multi-omics with artificial intelligence, establishing innovative research models, and regulating the tumor microenvironment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.