ArticleFrontiers in nutrition2026
Development and multi-cohort validation of a sarcopenia-inflammation index for predicting all-cause mortality in patients with chronic kidney disease.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Sarcopenia and chronic systemic inflammation frequently co-occur in chronic kidney disease (CKD), collectively driving poor prognosis. Yet current clinical practice lacks an integrated metric to quantify their combined prognostic impact. This study aimed to develop and validate a novel Sarcopenia-Inflammation (SI) Index for predicting all-cause mortality in CKD patients. Methods: This prospective multi-cohort study utilized the C-OPTION cohort ( Results: Among 4,895 CKD patients, multivariate Cox regression identified sarcopenia (HR: 4.582-5.947) and high inflammatory status (HR: 1.43-2.41) as independent mortality determinants with additive effects (interaction Conclusion: The SI Index is a potent, reproducible prognostic tool that integrates muscle decline and systemic inflammation to enhance all-cause mortality prediction in CKD, providing a quantitative basis for identifying high-risk patients and guiding personalized intervention strategies.
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