Evidence map›Paper›PMID 42707301›Full record

ArticleIn silico pharmacology2026

Design, synthesis, drug-likeness, and molecular dynamics evaluations of monobrominated amathamide G analogs as potential ligands for D2-like dopamine receptors.

Angélica Navarrete-Gutiérrez, Octavio Frías-Aviña, Julio Montes-Ávila, Raúl Argüello-García, Edar O Pech-Santiago, Gerardo Aguirre-Hernández

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In silico pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Angélica Navarrete-GutiérrezCentro de Graduados e Investigación en Química, Tecnológico Nacional de México/IT de Tijuana, Tijuana, B.C. Mexico.
Octavio Frías-AviñaCentro de Graduados e Investigación en Química, Tecnológico Nacional de México/IT de Tijuana, Tijuana, B.C. Mexico.
Julio Montes-ÁvilaFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán, Sin. Mexico.
Raúl Argüello-GarcíaDepartamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.
Edar O Pech-SantiagoDepartamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.
Gerardo Aguirre-HernándezCentro de Graduados e Investigación en Química, Tecnológico Nacional de México/IT de Tijuana, Tijuana, B.C. Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dopamine receptors (DRs) are key modulators of physiological and behavioral responses in the central nervous system (CNS), playing a major role in psychotic disorders. Among these, the D2-like members D2R, D3R and D4R are particularly attractive therapeutic targets for the development of novel compounds derived from both synthetic and natural sources. The marine bryozoan Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s40203-026-00741-1.

Indexed as

Amathamide G derivativesBrominated alkaloidsD2-like dopamine receptorsMolecular dockingMolecular dynamics simulationsPharmacological predictions

Identifiers

PMID42707301
PMCPMC13547561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.