ArticleFrontiers in neural circuits2026
Paraventricular thalamic neurons respond to vagus nerve activation and modulate anxious behavior.
Article in Frontiers in neural circuits, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interoceptive signals reflecting internal bodily states influence emotional processing. The paraventricular thalamus (PVT) constitutes a key node within the interoceptive network, monitoring circulating humoral factors in the ventricles, and is thus considered to link interoceptive signals to emotion-related behaviors. Here, we demonstrate that the vagus nerve (VN), a principal afferent pathway for interoceptive signaling, also affects PVT neuronal activity in mice. Left vagus nerve stimulation (VNS) induced pronounced c-Fos expression in PVT neurons and elicited transient increases and decreases in neuronal spike rates across all PVT subregions. These VNS-responsive neuronal populations were distinct from those exhibiting transient-to-sustained delayed responses following lipopolysaccharide injection after vagotomy, which selectively activates VN-independent pathways, including humoral factors. VNS-responsive PVT neurons projected to limbic structures and modulated anxiety-like behavior. Taken together, these findings demonstrate that PVT neuronal populations integrate and relay interoceptive signals across multiple pathways and timescales, thereby playing a pivotal role in linking vagus nerve-related bodily states to emotional responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.