ArticleFrontiers in microbiology2026
Bacterial and fungal co-colonization alters
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: On the skin, bacteria and fungi form mixed communities whose interactions can reshape both microbial physiology and host tissue, yet the microbial mechanisms remain poorly defined. Although polymicrobial colonization severity often exceeds the effects of individual pathogens in these conditions, the mechanism driving this synergy is unclear. Methods: We used a three-dimensional reconstructed human epidermis to characterize how co-colonization by Results: Co-colonized tissue thickened in the viable layers rather than the stratum corneum, a pattern absent from both monocultures whereas Discussion: Barrier disruption in this model therefore emerges from the two-species condition rather than from either organism which offers one explanation for why polymicrobial colonization tracks with severity in inflammatory skin disease.
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