Evidence map›Paper›PMID 42707141›Full record

ArticleiScience2026

A stromal β-defensin, DEFB124, contributes to cutaneous host defense against

Aaroh Joshi, Tomofumi Numata, Andrea Roso Mares, Hung Chan, Tatsuya Dokoshi, Anna Schwarz, Petra Kotzbeck, Jean-François Nicolas, Marc Vocanson, Peter Wolf and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aaroh JoshiDepartment of Dermatology and Venereology, Medical University of Graz, 8010 Graz, Austria.
Tomofumi NumataDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Andrea Roso MaresDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Hung ChanDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Tatsuya DokoshiDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Anna SchwarzCOREMED -Centre for Regenerative and Precision Medicine, Joanneum Research Forschungsgesellschaft mbH, Graz, Austria.
Petra KotzbeckCOREMED -Centre for Regenerative and Precision Medicine, Joanneum Research Forschungsgesellschaft mbH, Graz, Austria.
Jean-François NicolasCIRI, Centre International de Recherche en Infectiologie, INSERM, U1111, Université de Lyon 1, Ecole Normale Supérieure de Lyon, CNRS, UMR 5308, Lyon, France.
Marc VocansonCIRI, Centre International de Recherche en Infectiologie, INSERM, U1111, Université de Lyon 1, Ecole Normale Supérieure de Lyon, CNRS, UMR 5308, Lyon, France.
Peter WolfDepartment of Dermatology and Venereology, Medical University of Graz, 8010 Graz, Austria.
Vijaykumar PatraDepartment of Dermatology and Venereology, Medical University of Graz, 8010 Graz, Austria.
Richard L GalloDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.

Funding

Microbiology and Metagenomics CoreP50AR080594 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$9.2M
Microbiome Function in Atopic DermatitisU01AI152038 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo · 2020 to 2026
$3.3M
NIAID NIH HHS U01 AI152038NIAMS NIH HHS P50 AR080594
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are key components of barrier immunity and are traditionally attributed to epithelial cells and granulocytes. Here, we report human β-defensin 124 (DEFB124) as a previously uncharacterized AMP predominantly produced by dermal stromal cells. Transcriptomic analyses across independent therapeutic cohorts showed consistent induction of DEFB124 during the restoration of skin homeostasis in atopic dermatitis (AD). Spatial transcriptomics, qPCR, and protein analyses localized DEFB124 expression to dermal fibroblasts and adipocytes. The murine ortholog β-defensin 25 (Defb25) showed a similar stromal expression pattern, was induced following intradermal

Indexed as

antimicrobial peptidesatopic dermatitisdefensinsfibroblastsinfectioninnate immunityphototherapyS. aureusstromal cells

Identifiers

PMID42707141
PMCPMC13546879

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.