Evidence map›Paper›PMID 42707130›Full record

ArticleiScience2026

Stroma-oriented tumor microenvironment facilitates intraosseous ameloblastoma tumor growth.

Da-Yo Yuh, Chi-Ju Yao, Chia-Yu Chen, Ching-Yi Wu, Jian-Liang Chou, Hui-Na Chou, Ling-Yu Kung, Yi-Tzu Chen, Wei-Chin Chang, Yuan-Wu Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Da-Yo YuhInstitute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chi-Ju YaoInstitute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chia-Yu ChenInstitute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ching-Yi WuInstitute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Jian-Liang ChouInstrument Center, National Defense Medical University, Taipei, Taiwan.
Hui-Na ChouInstitute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ling-Yu KungSchool of Dentistry, College of Oral Medicine, National Defense Medical University, Taipei, Taiwan.
Yi-Tzu ChenSchool of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
Wei-Chin ChangSchool of Dentistry, College of Oral Medicine, National Defense Medical University, Taipei, Taiwan.
Yuan-Wu ChenSchool of Dentistry, College of Oral Medicine, National Defense Medical University, Taipei, Taiwan.
Qunzhou ZhangDepartment of Oral and Maxillofacial Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
Anh D LeDepartment of Oral and Maxillofacial Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
Ting-Han ChangInstitute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ameloblastoma (AM) is a locally aggressive odontogenic epithelial tumor with poorly understood intraosseous pathogenesis. Here, we established an orthotopic intraosseous mouse model using AM epithelial cells in combination with AM-derived mesenchymal stromal cells (AMMSCs) or their secretome. AMMSC-derived extracellular vesicle-enriched secretome enhances stemness, epithelial-mesenchymal transition (EMT) phenotypes, and tumorigenic ability of AM epithelial cells. A unique signature of microRNAs in AMMSC-derived secretome is functionally associated with the upregulation of EMT-regulatory transcription factors in tumor epithelial cells. Single-nucleus assay for transposase-accessible chromatin (ATAC) and RNA sequencing revealed dynamic EMT states in primary human AM-derived epithelial cells treated with paired AMMSC-derived secretome. This study suggests that AMMSCs and their secretome drive orthotopic AM tumor development by promoting tumor epithelial cell proliferation, EMT, and vascular formation in the tumor microenvironment. This stromal-oriented orthotopic model provides a clinically relevant platform for dissecting tumor-stroma crosstalk and identifying therapeutic vulnerabilities in AM.

Indexed as

ameloblastomamesenchymal stromal cellsmiRNAorthotopic mouse modelsecretomesingle-nucleus ATAC and RNA sequencetumor microenvironment

Identifiers

PMID42707130
PMCPMC13546885

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.