Evidence map›Paper›PMID 42707079›Full record

ArticleiScience2026

Differential activation of TCA cycle activity and PDH flux by dichloroacetate in skeletal muscle measured by hyperpolarized [2-

Sung-Han Lin, Andrew Cho, Mai T Huynh, Zohreh Erfani, Blanka Kucejova, Sasanka Wathukara Dewage, Thomas Jue, Xiaorong Fu, Zoltán Kovács, Shawn C Burgess and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sung-Han LinAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Andrew ChoDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mai T HuynhAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zohreh ErfaniAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Blanka KucejovaCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sasanka Wathukara DewageAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Thomas JueDepartment of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA.
Xiaorong FuCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zoltán KovácsAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shawn C BurgessCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jae Mo ParkAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Funding

UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4M
Pyruvate and acetate metabolism after TBI: implications for cerebral energy metabolismR01NS107409 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PARK, JAE MO · 2020 to 2024
$2.7M
Development of early metabolic imaging biomarkers for muscular dystrophy and cardiomyopathy in patientsR01HL170039 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI PRADEEP P.A. MAMMEN, Jae Mo Park · 2024 to 2026
$2.2M
A Clinical MR Scanner for Imaging Hyperpolarized Carbon-13S10RR029119 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2011 to 2011
$2.2M
Training Clinician Scientists as Outstanding Clinicians and Imaging ScientistsT32EB028093 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI ROBERT F MATTREY, Takeshi Yokoo · 2019 to 2026
$1.5M
A Clinical Polarizer for Carbon-13 (SpinLab)S10OD018468 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2015 to 2015
$1.0M
A liquid helium-free preclinical polarizer for hyperpolarized 13C metabolic imagingS10OD028490 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI WANSAPURA, JANAKA · 2020 to 2020
$600k
NCRR NIH HHS S10 RR029119NHLBI NIH HHS R01 HL170039NIBIB NIH HHS T32 EB028093NIDDK NIH HHS P30 DK127984NIH HHS S10 OD018468NIH HHS S10 OD028490NINDS NIH HHS R01 NS107409
6 · The paper itself

Abstract

Despite the central role of skeletal muscle bioenergetics in whole-body metabolic health, assessing mitochondrial oxidative phosphorylation and tricarboxylic acid (TCA) cycle activity

Indexed as

acetyl-L-carnitinedichloroacetatehyperpolarizedoxidative phosphorylationpyruvatepyruvate dehydrogenaseskeletal muscleTCA cycle

Identifiers

PMID42707079
PMCPMC13546930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.