Evidence map›Paper›PMID 42707074›Full record

ArticleFrontiers in oncology2026

Sertoli cell tumor in familial adenomatous polyposis: a case report.

Chandra Kakarala, Katie Bussing, Reema Patel, Jessica Moss, Zin W Myint

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chandra KakaralaDepartment of Internal Medicine, University of Kentucky, Lexington, KY, United States.
Katie BussingDepartment of Pathology, University of Kentucky, Lexington, KY, United States.
Reema PatelMarkey Cancer Center, University of Kentucky, Lexington, KY, United States.
Jessica MossMarkey Cancer Center, University of Kentucky, Lexington, KY, United States.
Zin W MyintMarkey Cancer Center, University of Kentucky, Lexington, KY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Familial adenomatous polyposis is known to progress into colorectal cancer, and extra-intestinal malignancies have also been reported. However, testicular sex cord stromal tumors are very rarely noted in association. In this study, we report the case of a 50-year-old man with genetically confirmed FAP and adenocarcinoma of the colon who was incidentally found to have a testicular lesion. Radial orchiectomy was performed, and histopathologic examination confirmed a Sertoli cell tumor without high-risk features. This tumor was found to have diffuse expression of nuclear beta-catenin, a marker for Wnt pathway activation, suggesting an abnormal CTNNB1 or APC variant. This suggests a possible link between germline APC mutations and Sertoli cell tumor development.

Indexed as

familial adenomatous polyposisSertoli cell tumorsex cord-stromal tumor of the testistesticular tumorWnt pathway

Identifiers

PMID42707074
PMCPMC13546995

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.