Evidence map›Paper›PMID 42707066›Full record

ArticleiScience2026

CASZ1 regulates the maturation of outer hair cells and is required for hearing in mice.

Yoko Nakano, Elizabeth C Driver, Ning Hu, Braulio Peguero, Susan C Wiechert, Erich T Boger, Chantal Allamargot, Rebecca Hipp, Angelika Doetzlhofer, Steven H Green and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yoko NakanoDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Elizabeth C DriverLaboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA.
Ning HuDepartment of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA 52242, USA.
Braulio PegueroLaboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA.
Susan C WiechertDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Erich T BogerGenomics and Computational Biology Core, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA.
Chantal AllamargotCentral Microscopy Research Facility, University of Iowa, Iowa City, IA 52242, USA.
Rebecca HippLaboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA.
Angelika DoetzlhoferThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Steven H GreenDepartment of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA 52242, USA.
Robert J MorellGenomics and Computational Biology Core, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA.
Matthew W KelleyLaboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA.
Botond BánfiDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

Funding

Notch Signaling Pathways in Auditory Supporting Cell Differentiation and MaintenanceR01DC011571 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI DOETZLHOFER, ANGELIKA · 2011 to 2020
$3.8M
Transcriptional regulation of hair cell development in the hearing organR01DC014953 · NIDCD · UNIVERSITY OF IOWA · PI Botond Banfi · 2016 to 2026
$3.6M
INTEGRATIVE MECHANISMS OF CORTICAL NEURONSR01DC000086 · NIDCD · YALE UNIVERSITY · PI SHEPHERD, GORDON · 1989 to 2010
$3.6M
Hair Cell Development in the Mammalian CochleaZ01DC000059 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI KELLEY, MATTHEW W · 2000 to 2008
$1.9M
POSTDOCTORAL RESEARCH TRAINING IN OTOLARYNGOLOGYT32DC000059 · NIDCD · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ANDERSON, JOHN H · 1999 to 2003
$453k
Intramural NIH HHS Z01 DC000059NIDCD NIH HHS R01 DC000086NIDCD NIH HHS R01 DC011571NIDCD NIH HHS R01 DC014953NIDCD NIH HHS T32 DC000059
6 · The paper itself

Abstract

The transcription factor ATOH1 is a master regulator of mechanosensory hair-cell (HC) development in the ear. Here, we report that its target gene

Indexed as

CASZ1CORO2Agene expression regulation in hair cellshair cell developmenthair cellshearinginner earorgan of Corti

Identifiers

PMID42707066
PMCPMC13546880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.