Evidence map›Paper›PMID 42706929›Full record

ArticleBioMed research international2026

Targeted Delivery of Triptolide Via Folate-Functionalized Pluronic Micelles Enhances Anti-Melanoma Activity by Inducing Reactive Oxygen Species Accumulation.

Genying Zhuang, Yanli Chen, Xiuli Gao, Jianwei Fu, Jianshui Mao

Abstract read
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In one paragraph

Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Genying ZhuangDepartment of Stomatology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China, zju.edu.cn.ORCID https://orcid.org/0009-0001-2227-4235
Yanli ChenDepartment of Stomatology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China, zju.edu.cn.ORCID https://orcid.org/0009-0004-9399-7731
Xiuli GaoDepartment of Stomatology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China, zju.edu.cn.ORCID https://orcid.org/0009-0008-2112-5669
Jianwei FuDepartment of Stomatology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China, zju.edu.cn.ORCID https://orcid.org/0009-0006-3704-6098
Jianshui MaoDepartment of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China, zju.edu.cn.ORCID https://orcid.org/0009-0006-4693-5110

Funding

National Natural Science Foundation of China 81802684
6 · The paper itself

Abstract

Melanoma remains a highly lethal malignancy, often associated with limited therapeutic efficacy and substantial systemic toxicity caused by conventional chemotherapy. Triptolide (TP) exhibits potent antitumor activity, but its clinical application is limited by poor aqueous solubility and a narrow therapeutic window. In this study, folate-decorated Pluronic nanomicelles (TP-FPNPs) were developed to enhance TP delivery. The resulting spherical micelles, with an average diameter of 152 nm, exhibited an encapsulation efficiency of 79% and sustained drug release for up to 48 h. By targeting folate receptors (FRs), TP-FPNPs increased cellular uptake in B16F10 and reduced the IC

Indexed as

DiterpenesDrug Delivery SystemsFolic AcidMelanomaMelanoma, ExperimentalMicellesPhenanthrenesPoloxamerReactive Oxygen SpeciesAnimalsApoptosisCell Line, TumorEpoxy CompoundsHumansHuman Umbilical Vein Endothelial CellsMiceDiterpenesEpoxy CompoundsFolic AcidMicellesPhenanthrenesPoloxamerReactive Oxygen Speciestriptolide

Identifiers

PMID42706929

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.