ArticleCNS neuroscience & therapeutics2026
Posture-Related Regional Homogeneity Abnormalities in Cerebral Small Vessel Disease: A Multi-Position MRI Study.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionCerebral small vessel disease (CSVD) is associated with altered spontaneous brain activity on resting-state functional magnetic resonance imaging (rs-fMRI). However, MRI studies usually overlook the potential effects of postural change. This study characterized posture-related alterations in spontaneous brain activity in CSVD patients. MATERIALS AND
methodsForty-one CSVD patients and 30 normal controls (NCs) underwent multi-position MRI, including upright and supine rs-fMRI. Amplitude of low-frequency fluctuations (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were calculated, and supine-upright differences (Δ) were derived. Mixed-design ANOVA assessed group, position, and interaction effects. Within-group and between-group differences were examined, followed by cognition-related analyses.
resultsThe main effect of posture on ReHo was observed in frontal, temporal, and parietal cortices and deep gray nuclei. In the upright position, CSVD patients had higher ReHo in the right anterior cingulate gyrus than NCs, which was associated with worse global cognitive function and a higher composite CSVD score. CSVD patients also exhibited widespread posture-related ReHo alterations. Regression analyses demonstrated that ΔReHo in the left hippocampus was positively associated with memory function, whereas ΔReHo in the right putamen and left calcarine cortex was associated with the composite CSVD score.
conclusionUpright imaging and upright-supine comparison may help unmask latent posture-related ReHo abnormalities in patients with CSVD.
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