ArticleCancer medicine2026
Colorectal Polyp Occurrence Associated With the ZMIZ1-AS1 rs704017 Variant and Hypertension Among Taiwan Biobank Participants.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Colorectal polyps (CPs) are recognized precursors of colorectal cancer (CRC), which remains a major global public health challenge, ranking third in incidence and second in cancer-related mortality worldwide. This study investigated the associations of hypertension and the zinc finger MIZ-type containing 1 antisense RNA 1 (ZMIZ1-AS1) variant (rs704017) with the odds of CP among participants in the Taiwan Biobank (TWB). Data from the TWB (2008-2015) were linked to the National Health Insurance Research Database (NHIRD, 1998-2015), yielding 8970 participants aged 30-70 years. Multiple logistic regression models were used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for CPs according to hypertension status and rs704017 genotype. The distribution of ZMIZ1-AS1 rs704017 genotypes differed significantly between CP cases and controls (p = 0.001). Individuals carrying the rs704017 AG + GG genotype had higher odds of CPs than those with the AA genotype (aOR = 1.39, 95% CI: 1.16-1.66). Hypertension alone was not significantly associated with CP odds; however, a significant interaction was observed between hypertension and rs704017 (p = 0.029). Compared with non-hypertensive individuals with the AA genotype, the aOR was 1.62 (95% CI, 1.29-2.03) for non-hypertensive individuals with AG + GG, 1.45 (95% CI, 1.09-1.95) for hypertensive individuals with AA, and 1.56 (95% CI, 1.16-2.08) for hypertensive individuals with AG + GG. In conclusion, the ZMIZ1-AS1 rs704017 AG + GG genotype was independently associated with increased odds of CP, whereas hypertension alone was not. However, the association between the rs704017 variant and CP appeared stronger among individuals with hypertension, suggesting a potential interaction between genetic susceptibility and hypertension.
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