Evidence map›Paper›PMID 42706610›Full record

ArticleVirulence2026

Immunogenicity evaluation of recombinant rabies virus-vectored multivalent vaccines expressing feline calicivirus VP1 and feline herpesvirus 1 gB/gD genes.

Yang Wang, Yueze Wang, Songze Zhao, Hongling He, Xiaolong Li, Yinyi Liang, Jiahao Wang, Lerong Xin, Nuan Chen, Wanxing Xie and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yang WangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Yueze WangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Songze ZhaoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Hongling HeCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Xiaolong LiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Yinyi LiangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Jiahao WangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Lerong XinCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Nuan ChenCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Wanxing XieCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Shile HuangDepartment of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Jun LuoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.ORCID 0000-0003-4422-9619
Xiaofeng GuoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.ORCID 0000-0003-2896-3629

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feline calicivirus (FCV) and feline herpesvirus 1 (FHV-1) are major pathogens threatening feline health, and prophylactic immunity remains the primary preventive approach. To develop a safe and effective multivalent vaccine against the two viruses, two recombinant rabies virus (RABV) vaccines expressing the FCV VP1 and FHV-1 gB/gD genes were constructed. The exogenous genes showed stable inheritance following serial viral passages, and the recombinant RABVs exhibited growth kinetics comparable to the parental strain, with a delayed peak titer. After verifying the viral pathogenicity, the recombinant RABV vaccines elicited specific IgG antibodies against VP1, gB, and gD, as well as neutralizing antibodies against FCV, FHV-1, and RABV in mice. Immunized mice were also protected against lethal RABV challenge. In cats, the vaccines induced neutralizing antibodies against the three pathogens, and immunized cats showed milder clinical signs and less severe histopathological lesions following FHV-1 and FCV challenge. Collectively, these findings indicate that the two recombinant vaccines induce robust humoral immune responses against FCV, FHV-1, and RABV in both mice and cats and confer protection against viral challenges.

Indexed as

Calicivirus, FelineImmunogenicity, VaccineRabiesRabies VaccinesRabies virusViral VaccinesAnimalsAntibodies, NeutralizingAntibodies, ViralCaliciviridae InfectionsCat DiseasesCatsFemaleHerpesviridaeHerpesviridae InfectionsImmunoglobulin GAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GRabies VaccinesVaccines, CombinedVaccines, SyntheticViral Vaccinesfeline calicivirusfeline herpesvirus 1neutralizing antibodyRabies virusvaccine

Identifiers

PMID42706610
PMCPMC13556961

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.