Evidence map›Paper›PMID 42706375›Full record

ArticleExperimental & molecular medicine2026

Adrenomedullin from spinal cord injury drives heterotopic ossification in skeletal muscle via a neuro-immune-bone axis.

Jiewen Chen, Zilong Wang, Xiaolin Zeng, Xiaoyu Wu, Gang Li, Nanyan Miao, Yilong Deng, Di Zhang, Xi Chen, Hongxi Lai and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiewen Chen *Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zilong Wang *Guangdong Province Key Laboratory of Orthopaedics and Traumatology, Guangzhou, China.ORCID http://orcid.org/0009-0001-6573-3120
Xiaolin Zeng *Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Xiaoyu WuGuangdong Province Key Laboratory of Orthopaedics and Traumatology, Guangzhou, China.
Gang LiDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0001-6891-7446
Nanyan MiaoDepartment of Plastic Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Yilong DengDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Di ZhangDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xi ChenFaculty of Medicine, Macau University of Science and Technology, Taipa, China.
Hongxi LaiDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yong WanDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. wanyong@mail.sysu.edu.cn.
Le WangDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. wangle3@mail.sysu.edu.cn.
Xiang LiDepartment of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. lixiang257@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-4869-7041

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82203677National Natural Science Foundation of China (National Science Foundation of China) 82572747
6 · The paper itself

Abstract

Neurological heterotopic ossification can rapidly arise in the periarticular muscles following spinal cord injury. However, the specific mechanism of how the injured central nervous system regulates heterotopic bone formation in peripheral tissues remains largely unexplored. Here we first demonstrate through single-cell RNA sequencing and spatial transcriptomic analysis that fibroadipogenic progenitor cells (FAPs) contribute to heterotopic ossification in injured muscle tissues following spinal cord injury. Mechanistically, we define a neuro-immune-bone axis in which endothelial tip cells within the injured spinal cord serve as a major source of adrenomedullin (ADM), which acts on muscle-resident regulatory T cells (T

Indexed as

AdrenomedullinMuscle, SkeletalOssification, HeterotopicSpinal Cord InjuriesAnimalsBone Morphogenetic Protein 2Cell DifferentiationMiceOsteogenesisReceptor Activity-Modifying Protein 2T-Lymphocytes, RegulatoryAdrenomedullinBone Morphogenetic Protein 2Ramp2 protein, mouseReceptor Activity-Modifying Protein 2

Identifiers

PMID42706375
PMCPMC13633261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.