Evidence map›Paper›PMID 42706326›Full record

ArticleNature chemical biology2026

Directed evolution of Lantern enables rapid RNA and protein proximity labeling.

Yuxin Fang, Ziqi Ren, Fu Zheng, Ruixiang Wang, Songrui Zhao, Yihai Zhang, Wentao Wang, Chen Li, Luorong Liu-Yang, Chang Lin and 2 more

Abstract read
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In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuxin Fang *College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Ziqi Ren *College of Chemistry and Molecular Engineering, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-3000-8228
Fu Zheng *College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Ruixiang Wang *College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Songrui ZhaoAcademy for Advanced Interdisciplinary Studies, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Yihai ZhangAcademy for Advanced Interdisciplinary Studies, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Wentao WangCollege of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Chen LiAcademy for Advanced Interdisciplinary Studies, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Luorong Liu-YangCollege of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Chang LinCollege of Chemistry and Molecular Engineering, Peking University, Beijing, China.ORCID http://orcid.org/0000-0003-0445-6964
Jun LiuAcademy for Advanced Interdisciplinary Studies, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-2498-9963
Peng ZouCollege of Chemistry and Molecular Engineering, Peking University, Beijing, China. zoupeng@pku.edu.cn.ORCID http://orcid.org/0000-0002-9798-5242

Funding

Bayer Bayer Investigator AwardMinistry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2022YFA1304700National Natural Science Foundation of China (National Science Foundation of China) 32088101
6 · The paper itself

Abstract

In eukaryotic cells, the precise spatial localization of RNAs and proteins is essential for proper cellular function. Genetically encoded photocatalytic proximity labeling techniques have expanded our ability to map subcellular proteomes and transcriptomes, but their temporal resolution remains limited. Here we introduce Lantern, an engineered flavoprotein optimized via directed evolution, which enables sub‑minute, spatially resolved labeling of cellular biomolecules. Lantern is targetable to diverse subcellular compartments, including the endoplasmic reticulum (ER), mitochondria and stress granules (SGs), to map local transcriptomes (CAP-seq) and proteomes (CAP-MS). Using Lantern, we observed that N

Identifiers

PMID42706326

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.