Evidence map›Paper›PMID 42706241›Full record

ArticleNature communications2026

Nuclear localization of the glutaminyl-tRNA synthetase QARS reveals its role in DNA damage response in ovarian cancer.

Martina Serafini, Francesca Di Fazio, Yann Kieffer, Lounes Djerroudi, Léonie Dec, Michael Richard, Yann Aubert, Franco Marchesoni-Acland, Manuel D Diaz-Munoz, Anne Vincent-Salomon and 5 more

Abstract read
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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Martina SerafiniStress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France.
Francesca Di Fazio *Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France.
Yann Kieffer *Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France.ORCID http://orcid.org/0000-0003-2722-3071
Lounes DjerroudiStress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France.ORCID http://orcid.org/0000-0002-5007-2964
Léonie DecInstitut Curie, PSL Research University, CurieCoreTech Mass Spectrometry Proteomics, Paris, France.ORCID http://orcid.org/0009-0008-2475-0275
Michael RichardInstitut Curie, PSL Research University, CurieCoreTech Mass Spectrometry Proteomics, Paris, France.ORCID http://orcid.org/0000-0002-9907-9702
Yann AubertUniversity of Toulouse, Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), Inserm UMR1291, CNRS UMR5051, CHU Purpan, Toulouse, France.ORCID http://orcid.org/0000-0002-9769-6133
Franco Marchesoni-AclandUniversité Paris-Saclay, ENS Paris-Saclay, CNRS UMR9010, Centre Borelli, Gif-sur-Yvette, France.
Manuel D Diaz-MunozUniversity of Toulouse, Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), Inserm UMR1291, CNRS UMR5051, CHU Purpan, Toulouse, France.ORCID http://orcid.org/0000-0002-9227-7474
Anne Vincent-SalomonStress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France.ORCID http://orcid.org/0000-0001-5754-5771
Stéphan VagnerInstitut Curie, PSL Research University, CNRS UMR3348, Inserm, Orsay, France.ORCID http://orcid.org/0000-0003-1452-7164
Damarys LoewInstitut Curie, PSL Research University, CurieCoreTech Mass Spectrometry Proteomics, Paris, France.ORCID http://orcid.org/0000-0002-9111-8842
Raphael CeccaldiInserm U1339, CNRS UMR3666, 26 rue d'Ulm, Paris, France.ORCID http://orcid.org/0000-0003-3049-4278
Fatima Mechta-GrigoriouStress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France. fatima.mechta-grigoriou@curie.fr.ORCID http://orcid.org/0000-0002-3751-6989
Virginie MieuletStress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France. virginie.mieulet@inserm.fr.ORCID http://orcid.org/0000-0001-5104-639X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uncovering novel mechanisms controlling DNA damage response (DDR) is essential to better understand the molecular features of high-grade serous ovarian cancers (HGSOC), which remain a clinical challenge. Here, we demonstrate that the glutaminyl-tRNA-synthetase QARS is a key player in DDR. We show that QARS is regulated at translational level by the MAPK pathway in HGSOC and controls homologous recombination (HR) through a translation-independent mechanism. Analyses combining RNA sequencing, immunohistochemistry, proteomic data and functional assays from HGSOC patient cohorts and relevant cellular models reveal that QARS promotes DNA repair via the HR pathway. Interestingly, we uncover that QARS is located in the nucleus and is enriched at chromatin upon DNA damage. Nuclear QARS controls HR by interacting with the nuclear autoantigen SP100, a major component of PML-nuclear bodies (PML-NB), that are regulatory hubs for DNA repair proteins. Our data highlight nuclear functions and mechanisms for QARS involving SP100, PML-NB and MRE11 that enhance HR in HGSOC.

Indexed as

Amino Acyl-tRNA SynthetasesCell NucleusDNA DamageOvarian NeoplasmsAntigens, NuclearAutoantigensCell Line, TumorChromatinDNA RepairFemaleHomologous RecombinationHumansMRE11 Homologue ProteinAmino Acyl-tRNA SynthetasesAntigens, NuclearAutoantigensChromatinMRE11 Homologue ProteinMRE11 protein, human

Identifiers

PMID42706241
PMCPMC13550464

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.