Evidence map›Paper›PMID 42705858›Full record

ReviewZhongguo fei ai za zhi = Chinese journal of lung cancer2026

[Tumor Cell and Brain Microenvironment Interactions in Non-small Cell Lung Cancer 
Brain Metastasis: Mechanisms and Emerging Insights].

Heqi Yang, Qinghua Zhou

Abstract readReviewEnglish Abstract
In one paragraph

Review in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Heqi YangLung Cancer Institute/Lung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Qinghua ZhouLung Cancer Institute/Lung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain metastasis in non-small cell lung cancer (NSCLC) is shaped by continuous interactions between tumor cells and the brain-specific microenvironment. Vascular, glial and immune components contribute to intracranial colonization, immune escape and therapeutic resistance, while single-cell and spatial omics reveal heterogeneity in cellular states, communication networks and spatial niches. This review summarizes NSCLC brain metastasis and intracranial colonization, the brain metastatic microenvironment and tumor-microenvironment interactions, and discusses the heterogeneity revealed by single-cell and spatial omics and its potential relevance to therapeutic response and patient stratification.
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Indexed as

Brain NeoplasmsCarcinoma, Non-Small-Cell LungLung NeoplasmsTumor MicroenvironmentAnimalsHumansBrain metastasisLung neoplasmsSingle-cell sequencingSpatial omicsTumor microenvironment

Identifiers

PMID42705858
PMCPMC13559066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.