ArticleChemMedChem2026
Substituent Effects of Heptamethine Cyanine Dyes on Drug Uptake in Patient-Derived Glioma Cells.
Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Brain tumors, specifically high-grade gliomas such as glioblastoma (GBM), are challenging to treat due to the presence of physiological barriers such as blood-brain barrier (BBB) and tumor heterogeneity. Designing drugs that address these brain tumor-specific drug discovery challenges will herald much-needed breakthroughs for this patient population. This study presents a proof of concept for the in vitro cellular activity of the multitargeted kinase inhibitor crizotinib conjugated to BBB-crossing heptamethine cyanine dyes decorated with various functional groups in four patient-derived GBM cell lines. We also present evidence of cellular uptake, which contributes to the observed improvement in potency of the conjugates.
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Registered trials
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