Observational studyBMJ open ophthalmology2026
Relationship between age, pseudophakia, diabetes mellitus and endothelial cell density in corneal donor tissue: a 10-year retrospective study.
Observational study in BMJ open ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the independent and combined effects of age, diabetes and pseudophakia on endothelial cell density (ECD), assessed both as a continuous measure and as a binary outcome using a commonly used reference threshold of <2000 cells/mm². METHODS AND ANALYSIS: This retrospective, observational, cross-sectional study analysed 681 donor corneas from 350 individuals recorded in the Rabin Medical Center, between 2014 and 2024. Baseline donor variables included age at donation, sex, diabetes status and lens status. ECD was measured centrally using Konan CellChek specular microscopy, which quantifies ECD based on manual marking of central endothelial cell centres. Generalised estimating equations were used to account for within-donor clustering, modelling ECD as both continuous and binary variables. Potential effect modification by pseudophakia was assessed in stratified models.
resultsMean donor age was 62.8 years; 37.1% had diabetes and 22.8% were pseudophakic. Diabetes was associated with lower ECD overall (β = -106 cells/mm²; 95% CI -205 to -7) and with increased odds of ECD <2000 (OR=1.91; 95% CI 1.13 to 3.21). However, this effect was only significant in non-pseudophakic eyes. Pseudophakia (OR=2.88; 95% CI 1.80 to 4.63) and older age (OR per year=1.05; 95% CI 1.03 to 1.07) were consistently associated with lower ECD and a higher likelihood of falling below threshold.
conclusionOlder age and pseudophakia were independently associated with increased risk of low ECD. In subgroup analyses, diabetes was linked to lower ECD only in non-pseudophakic eyes. However, formal statistical testing for interaction between diabetes and lens status was not significant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.