Evidence map›Paper›PMID 42705195›Full record

ArticlePoultry science2026

Effects of Ban Lian Zi Jin compound on intestinal barrier and apoptosis of Heat-stressed broilers.

Zongtao Zuo, Yongxin Liao, Yulin He, Yuqing Li, Jiahui Mei, Xiaoxiao Du, Yun Gao, Kailun Xi, Dayou Shi, Cui Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zongtao ZuoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: zuozt@stu.scau.edu.cn.
Yongxin LiaoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: liaoyongxin@stu.scau.edu.cn.
Yulin HeCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: heyulin@stu.scau.edu.cn.
Yuqing LiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: liyuuuuqing@stu.scau.edu.cn.
Jiahui MeiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: 20242029010@stu.scau.edu.cn.
Xiaoxiao DuCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: duxiaoxiao@stu.scau.edu.cn.
Yun GaoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: gaoyun@stu.scau.edu.cn.
Kailun XiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: xikailun@stu.scau.edu.cn.
Dayou ShiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Technology Research Center for Traditional Chinese Veterinary Medicine and Nature Medicine, Guangzhou, 510642, China; International Institute of Traditional Chinese Veterinary Medicine, Guangzhou, 510642, China. Electronic address: shidayou@scau.edu.cn.
Cui LiuCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: liuc@scau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat stress can damage the integrity of the intestinal barrier in broiler chickens. The aim of this study is to evaluate the protective and reparative effects and related mechanisms of Ban Lian Zi Jin (BLZJ) compound on the intestinal barrier function of heat stressed broiler chickens. Acute heat stress was induced in 216 broilers, which were randomly allocated to six treatment groups. Broilers in the treatment groups received BLZJ daily via dietary supplementation or drinking water, whereas the HS group was fed a basal diet with normal water only. LC-MS results indicate that components such as scopolamine and magnolol in BLZJ may alleviate heat stress-induced intestinal barrier damage through anti-inflammatory, antioxidant, and regulatory activities.Moreover, Supplementation with BLZJ significantly increasing the jejunum gene expression of TJPs (Occludin, Claudin-1, Claudin-5), MUCs (MUC2, E-cadherin) and the anti-apoptotic protein(BCL2)(P<0.05), significantly decreased the jejunum gene expression of pro-apoptotic factors (BAX, CYTC, caspase-3, caspase-9)(P < 0.05), enhanced the abundance of beneficial gut microbiota, and improved microbial community stability. In conclusion, BLZJ can repair intestinal barrier damage in heat stressed broiler chickens by enhancing tight junctions and mucin expression, regulating intestinal microbiota homeostasis, and inhibiting excessive intestinal mucosal apoptosis.

Indexed as

ApoptosiBLZJBroilerHeat stressIntestinal barrier function

Identifiers

PMID42705195
PMCPMC13572182

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.