ArticleJournal of veterinary internal medicine2026
Discriminatory performance of total calcium for ionized hypocalcemia and factors affecting ionized calcium in Assaf ewes during the pre- and post-lambing periods.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTotal calcium concentration (tCa) poorly reflects ionized hypocalcemia across species, and multiple factors influence ionized calcium concentration (iCa2+). These relationships have not been evaluated in Assaf ewes. HYPOTHESIS/
objectivesAssess the diagnostic accuracy of tCa for detecting hypocalcemia and identify factors associated with iCa2+ during pre- and post-lambing periods. ANIMALS: A total of 105 clinically healthy multiparous Assaf ewes from a commercial flock.
methodsProspective observational study. Venous blood samples were collected during pre- and post-lambing periods. Blood gas-electrolytes (pH, pCO₂, pO₂, HCO₃-, TCO₂, Na+, K+, iCa2+) and biochemical analyses (total protein, albumin, tCa, magnesium, phosphorus, β-hydroxybutyrate [BHB], glucose, alkaline phosphatase) were performed. Discriminatory performance of tCa was evaluated using area under the receiver operating characteristic curve (AUC) analysis. Variables associated with iCa2+ were assessed using multiple linear regression.
resultsDuring the pre-lambing period, tCa showed moderate diagnostic performance (AUC, 0.73; 95% CI, 0.57-0.87; sensitivity, 67%; specificity, 80%) at a cutoff of ≤ 2.42 mmol/L, whereas performance was poor for the post-lambing period (AUC, 0.59; 95% CI, 0.47-0.70; sensitivity, 97%; specificity, 31%) at ≤ 2.77 mmol/L. In multiple regression, tCa, BHB, pCO₂, and pO₂ were associated with iCa2+ during pre-lambing (adjusted R2 = 0.27, P < .001), whereas tCa, BHB, phosphorus, albumin, and Na+ were associated with the post-lambing period (adjusted R2 = 0.25, P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: iCa2+ varied by production stage and was influenced by several physiologic variables. Direct measurement of iCa2+ should be prioritized to improve the accuracy of hypocalcemia assessment in Assaf ewes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.