ArticleBioinformatics (Oxford, England)2026
peakScout-a biologist-friendly tool for bidirectional peak-gene mapping.
Article in Bioinformatics (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
motivationTranslating genomic peak data into biologically meaningful knowledge typically requires bioinformatics expertise, creating a barrier for non-technical users. We developed peakScout to bridge the gap between peaks, genes, and gene annotations, enabling users to quickly focus on biological context rather than bioinformatics skills, in a reproducible and robust fashion.
resultspeakScout is a command line and web-based program that performs bidirectional mapping between genomic peaks and genes. The peak-to-gene mode identifies which genes are potentially regulated by specific genomic regions, while the gene-to-peak mode reveals which regulatory elements might influence particular genes of interest. An algorithm for nearest-feature detection handles the complex spatial relationships between genomic elements, considering factors like distance constraints and feature overlaps. AVAILABILITY AND IMPLEMENTATION: The web version of peakScout is available at https://vandydata.github.io/peakScout/. The command line version is available at https://github.com/vandydata/peakScout and archived on Zenodo (https://doi.org/10.5281/zenodo.21211605) under the GNU Affero General Public License v3.0. Installation instructions, example datasets, and usage examples are provided in the GitHub repository README file.
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