Evidence map›Paper›PMID 42704568›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2026

Virtual bioequivalence-guided PBBM prediction for ibuprofen/diphenhydramine citrate tablets: impact of dissolution variability and clinical standard development.

Zilong Wang, Zhihai Cao, Chun Guo, Qian Zhang, Renpeng Zhou, Jian Chen, Feng Su, Wei Liu, Zhaoxing Chu, Liang Zheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zilong WangDepartment of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China.ORCID http://orcid.org/0009-0002-2158-9056
Zhihai CaoDepartment of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China.ORCID http://orcid.org/0009-0008-1920-4413
Chun GuoDepartment of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China.ORCID http://orcid.org/0009-0002-3527-8398
Qian ZhangDepartment of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China.ORCID http://orcid.org/0009-0009-8155-2918
Renpeng ZhouDepartment of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China.ORCID http://orcid.org/0000-0003-2629-0256
Jian ChenDepartment of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China.ORCID http://orcid.org/0000-0003-2600-6147
Feng SuHefei Institute of Pharmaceutical Industry, Co. Ltd, Hefei, China.ORCID http://orcid.org/0009-0002-5641-7115
Wei LiuHefei Institute of Pharmaceutical Industry, Co. Ltd, Hefei, China.ORCID http://orcid.org/0009-0000-5740-7774
Zhaoxing ChuHefei Institute of Pharmaceutical Industry, Co. Ltd, Hefei, China. chuzhaoxing@163.com.ORCID http://orcid.org/0000-0003-3347-7449
Liang ZhengDepartment of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China. zhengl@ahmu.edu.cn.ORCID http://orcid.org/0000-0002-4971-451X
Wei HuDepartment of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China. huwei@ahmu.edu.cn.ORCID http://orcid.org/0000-0002-4809-7601

Funding

Anhui Province Clinical Medical Research and Transformation Special Project 202304295107020021National Natural Science Foundation of China 82204527Natural Science Foundation of Anhui Province 2208085QH279
6 · The paper itself

Abstract

This study aimed to integrate in vitro dissolution testing, in vivo pharmacokinetic (PK) studies, and computational simulation to develop a physiologically based biopharmaceutics model (PBBM) for fixed-dose combination ibuprofen/diphenhydramine citrate tablets, thereby evaluating bioequivalence (BE) and establishing a dissolution safe space. Initially, a PBBM model was constructed using B

Indexed as

Physiologically Based Biopharmaceutics Model (PBBM); virtual bioequivalence (VBE); clinical relevant dissolution standards (CRDS)

Identifiers

PMID42704568
PMCPMC13550351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.