Evidence map›Paper›PMID 42704546›Full record

ArticleInfection2026

Cefepime/enmetazobactam for invasive infections caused by extended-spectrum beta-lactamase-producing Enterobacterales: a real-world case series.

Mario Karolyi, Dorit Stahl, Michelle Naegeli, Erich Pawelka, Alexander Zoufaly, Christoph Wenisch

Abstract read
PubMed Publisher
In one paragraph

Article in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mario Karolyi4th Medical Department with Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria. mario.karolyi@gmx.at.ORCID http://orcid.org/0000-0002-9870-2339
Dorit StahlHospital Hygiene and Infection Control, Klinik Landstraße, Vienna, Austria.
Michelle Naegeli4th Medical Department with Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria.ORCID http://orcid.org/0009-0008-4993-3115
Erich Pawelka4th Medical Department with Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria.ORCID http://orcid.org/0000-0003-0199-0539
Alexander Zoufaly4th Medical Department with Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria.
Christoph Wenisch4th Medical Department with Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present our retrospective case series of eight patients with either bloodstream infection, pneumonia or complicated intra-abdominal infection caused by extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) treated with cefepime/enmetazobactam. Treatment failure and 30-day all-cause mortality occurred in one patient each. Cefepime/enmetazobactam showed favorable clinical results and may represent a carbapenem-sparing treatment option in selected patients with invasive ESBL-E infections. Real-world data remain limited and further studies are needed to specify the most suitable patient population.

Indexed as

Antibiotic stewardshipCarbapenem-sparingESBL BSIESBL cIAIESBL pneumonia

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.