Evidence map›Paper›PMID 42704520›Full record

ArticleHuman cell2026

GMPS promotes cervical squamous cell carcinoma cell immune evasion through USP7-mediated deubiquitination of PDL1.

Yuanyuan Zhang, Wenyun Li, Qian Zhuo, Shaliya Abuduwufu, Jingjing Zhang

Abstract read
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In one paragraph

Article in Human cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuanyuan ZhangGynecology Department of Affiliated Tumor Hospital, Xinjiang Medical University, No. 789 Suzhou East Street, Ürümqi, 830000, Xinjiang, China. 519602409@qq.com.
Wenyun LiGynecology Department of Affiliated Tumor Hospital, Xinjiang Medical University, No. 789 Suzhou East Street, Ürümqi, 830000, Xinjiang, China.
Qian ZhuoGynecology Department of Affiliated Tumor Hospital, Xinjiang Medical University, No. 789 Suzhou East Street, Ürümqi, 830000, Xinjiang, China.
Shaliya AbuduwufuGynecology Department of Affiliated Tumor Hospital, Xinjiang Medical University, No. 789 Suzhou East Street, Ürümqi, 830000, Xinjiang, China.
Jingjing ZhangGynecology Department of Affiliated Tumor Hospital, Xinjiang Medical University, No. 789 Suzhou East Street, Ürümqi, 830000, Xinjiang, China.

Funding

"Tianshan Talents" High-Level Talent Training Program in Medicine and Health of Xinjiang Uygur Autonomous Region TSYC202301B076
6 · The paper itself

Abstract

Cervical squamous cell carcinoma (CSCC) is the most common subtype of cervical cancer (CC), which is a gynecological malignancy with poor survival. Immunotherapy is a promising approach to anti-CC. GMPS has been found to promote CC cell proliferation and inhibit apoptosis; however, whether it regulates immune evasion remains unknown. This study aimed to investigate the role of GMPS in CSCC and the molecular mechanism. In vitro experiments were performed to analyze cell proliferation and immune evasion, while in vivo experiments were conducted to assess the impact of GMPS on tumor growth and immune evasion. The results showed that GMPS expression was increased in CC tissues and cells. Knockdown of GMPS suppressed CSCC cell proliferation, enhanced the toxicity and activity of CD8

Indexed as

B7-H1 AntigenCarcinoma, Squamous CellImmune EvasionTumor EscapeUbiquitinationUbiquitin-Specific Peptidase 7Uterine Cervical NeoplasmsAnimalsApoptosisCell ProliferationFemaleGene ExpressionHumansImmunotherapyB7-H1 AntigenCD274 protein, humanUbiquitin-Specific Peptidase 7USP7 protein, humanCervical squamous cell carcinomaDeubiquitinationGMPSImmune evasionPDL1USP7

Identifiers

PMID42704520

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.