Evidence map›Paper›PMID 42704507›Full record

ArticleActa parasitologica2026

Integrated Experimental and Computational Investigation of Azobenzenoid Derivatives Against Trypanosomatid: RNA Editing Ligase 1 as a Potential Molecular Target.

Asif Khan, Rodolfo Bento Balbinot, Danielle Lazarin-Bidóia, Maira Gabriela Paetzold, Íris Nunes Seixas, Gustavo Nunes Ramos Silva, Maria Aparecida Fernandez, Celso Vataru Nakamura, Flavio Augusto Vicente Seixas

Abstract read
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Article in Acta parasitologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Asif KhanLaboratory of Structural Biochemistry, Department of Technology, State University of Maringá, Av. Ângelo Moreira da Fonseca, 1800, Pq Danielle, Umuarama, PR, 87506-370, Brazil.
Rodolfo Bento BalbinotTechnological Innovation Laboratory in the Pharmaceuticals and Cosmetics Development, State University of Maringá, Maringá, PR, Brazil.
Danielle Lazarin-BidóiaTechnological Innovation Laboratory in the Pharmaceuticals and Cosmetics Development, State University of Maringá, Maringá, PR, Brazil.
Maira Gabriela PaetzoldLaboratory of Structural Biochemistry, Department of Technology, State University of Maringá, Av. Ângelo Moreira da Fonseca, 1800, Pq Danielle, Umuarama, PR, 87506-370, Brazil.
Íris Nunes SeixasDepartment of Odontology, Paranaense University, Umuarama, PR, Brazil.
Gustavo Nunes Ramos SilvaDepartment of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Maria Aparecida FernandezDepartment of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, PR, Brazil.
Celso Vataru NakamuraTechnological Innovation Laboratory in the Pharmaceuticals and Cosmetics Development, State University of Maringá, Maringá, PR, Brazil.
Flavio Augusto Vicente SeixasLaboratory of Structural Biochemistry, Department of Technology, State University of Maringá, Av. Ângelo Moreira da Fonseca, 1800, Pq Danielle, Umuarama, PR, 87506-370, Brazil. favseixas@uem.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeglected tropical diseases caused by pathogenic protozoa, including Chagas Disease (etiological agent Trypanosoma cruzi) and leishmaniasis (etiological agent Leishmania spp.), are public health problems in many developing countries. AIMS AND METHODOLGY: Due to the lack of safe and effective therapies, the current study was designed to screen synthetic azobenzenoid derivatives using integrated in silico and in vitro assays.

resultsAmong the tested compounds, CaCS2 potentially inhibited promastigotes and amastigotes of Leishmania amazonensis and epimastigotes and trypomastigotes of Trypanosoma cruzi, while showing no cytotoxicity towards human J774A.1 and LLC-MK

conclusionInterestingly, CaCS2 was a specific ligand to REL1 and non cytotoxic to human cell lines, making it a promising scaffold for anti-trypanosomatid development.

Indexed as

Antiprotozoal AgentsCarbon-Oxygen LigasesLeishmaniaTrypanosoma cruziAnimalsCell LineHumansMitochondrial ProteinsMolecular Docking SimulationMolecular Dynamics SimulationAntiprotozoal AgentsCarbon-Oxygen LigasesMitochondrial ProteinsREL1 RNA ligase, Trypanosoma bruceiCytotoxicityDrug discoveryLeishmaniaMD simulationMolecular dockingRNA editing ligase 1Trypanosoma

Identifiers

PMID42704507
PMCPMC13550046

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.