Evidence map›Paper›PMID 42704414›Full record

ArticleOphthalmology and therapy2026

Effect of Photobiomodulation‑Based LED on Myopia Control in Children: An Exploratory Randomized Clinical Trial.

Yuye Duan, Ziyi Qi, Feiran Yu, Kaidi Xiang, Haotian Wu, Zhenglin Liu, Wei Feng, Zongyuan Ge, Haidong Zou, Xun Xu and 1 more

Registry-linked trialAbstract read
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In one paragraph

Article in Ophthalmology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07375589 (Exploratory Study on the Efficacy and Safety of LED Low-Intensity Red Light for Controlling Myopia Progression in Children and Adolescents), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07375589 nacompletednot on this map

Exploratory Study on the Efficacy and Safety of LED Low-Intensity Red Light for Controlling Myopia Progression in Children and Adolescents

TypeinterventionalSponsorShanghai Eye Disease Prevention and Treatment CenterRan2025 to 2025Enrolled40ConditionsMyopia, AmetropiaArmsRed light treatment with 1.6mW LED light source, Red light treatment with 0.001mW LED light source
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuye Duan *Shanghai Eye Disease Prevention and Treatment Center/Eye Hospital of Tongji University, National Clinical Research Center for Eye Diseases, Shanghai, China.
Ziyi Qi *Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Feiran YuSchool of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Kaidi XiangDepartment of Ophthalmology, The Affiliated People's Hospital of Ningbo University/The Eye Hospital of Wenzhou Medical University (Ningbo Branch), Ningbo, Zhejiang, China.
Haotian WuDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhenglin LiuDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei FengFaculty of Information Technology, Monash University, Melbourne, VIC, Australia.
Zongyuan GeFaculty of Information Technology, Monash University, Melbourne, VIC, Australia.
Haidong ZouShanghai Eye Disease Prevention and Treatment Center/Eye Hospital of Tongji University, National Clinical Research Center for Eye Diseases, Shanghai, China.
Xun XuShanghai Eye Disease Prevention and Treatment Center/Eye Hospital of Tongji University, National Clinical Research Center for Eye Diseases, Shanghai, China.
Xiangui HeShanghai Eye Disease Prevention and Treatment Center/Eye Hospital of Tongji University, National Clinical Research Center for Eye Diseases, Shanghai, China. xianhezi@163.com.ORCID http://orcid.org/0000-0002-8938-1879

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLaser-based repeated low-level red-light (RLRL) therapy may slow myopia progression, but evidence for lower-intensity noncoherent photobiomodulation-based light-emitting diode (PBM-LED) therapy remains limited. We evaluated its short-term efficacy and safety in children with myopia.

methodsIn this single-center, double-masked, sham-controlled exploratory trial, 40 children aged 8-12 years were randomized 1:1 to PBM-LED or sham treatment twice daily for 3 months. Primary outcomes were axial length (AL) and cycloplegic spherical equivalent (SE).

resultsAll participants completed follow-up. In eye-specific analyses, the intervention group showed less axial elongation, with significance only in the left eye at 3 months (difference, -0.056 mm; 95% confidence interval, -0.109 to -0.004; P = 0.036). Using participant-level means of both eyes, unadjusted 3-month differences were -0.059 mm for AL (P = 0.061) and 0.244 D for SE (P = 0.092); adjusted differences were not significant. Five eyes across both groups showed a 0.20-logMAR deterioration in uncorrected visual acuity at 3 months, but no eyes showed a 0.20-logMAR or greater decline in best-corrected visual acuity at 1 or 3 months. No serious adverse events or structural retinal abnormalities were observed.

conclusionsPBM-LED showed a preliminary short-term treatment signal, but the small sample, unilateral nominal finding, nonsignificant adjusted participant-level analyses, visual-acuity changes, and short follow-up preclude definitive efficacy or long-term safety conclusions.

trial registrationClinicalTrials.gov identifier NCT07375589.

Indexed as

AdolescentsChildrenLight-emitting diodeMyopiaPhotobiomodulation

Identifiers

PMID42704414

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.